The role of immune cells and mediators in preeclampsia

E Deer, O Herrock, N Campbell, D Cornelius… - Nature Reviews …, 2023‏ - nature.com
Preeclampsia is a hypertensive disorder of major concern in pregnancy than can lead to
intrauterine growth restriction, placental abruption and stillbirth. The pathophysiology of …

Animal models of preeclampsia: investigating pathophysiology and therapeutic targets

BA Bakrania, EM George, JP Granger - American Journal of Obstetrics and …, 2022‏ - Elsevier
Animal models have been critical in investigating the pathogenesis, mediators, and even
therapeutic options for a number of diseases, including preeclampsia. Preeclampsia is the …

[HTML][HTML] Relevance of real-time analyzers to determine mitochondrial quality in endothelial cells and oxidative stress in preeclampsia

PR Nunes, PF Oliveira, I Rebelo, VC Sandrim… - Vascular …, 2024‏ - Elsevier
Oxidative stress and mitochondrial dysfunction are important elements for the
pathophysiology of preeclampsia (PE), a multisystemic hypertensive syndrome of …

The role of mitochondrial dysfunction in preeclampsia: causative factor or collateral damage?

AN Smith, X Wang, DG Thomas… - American Journal of …, 2021‏ - academic.oup.com
Preeclampsia, new onset hypertension in pregnancy, affects~ 5%–10% of the world's
population. Preeclampsia is the leading cause of morbidity and mortality for both the mother …

[PDF][PDF] Preeclampsia and the kidney: pathophysiology and clinical implications

V Dines, S Suvakov, A Kattah, J Vermunt… - Comprehensive …, 2023‏ - researchgate.net
Preeclampsia and other hypertensive disorders of pregnancy are major contributors to
maternal morbidity and mortality worldwide. This group of disorders includes chronic …

Placental and renal pathways underlying pre-eclampsia

PE Andronikidi, E Orovou, E Mavrigiannaki… - International Journal of …, 2024‏ - mdpi.com
Pre-eclampsia is a serious complication of pregnancy characterized by a state of multiorgan
hypertensive disorders, with or without proteinuria and possible multiorgan dysfunction …

Metabolic theory of preeclampsia: Implications for maternal cardiovascular health

MM Manoharan, GC Montes… - American Journal …, 2024‏ - journals.physiology.org
Preeclampsia (PE) is a multisystemic disorder of pregnancy that not only causes perinatal
mortality and morbidity but also has a long-term toll on the maternal and fetal cardiovascular …

Tumor necrosis factor alpha (TNF-α) blockade improves natural killer cell (NK) activation, hypertension, and mitochondrial oxidative stress in a preclinical rat model of …

MW Cunningham, A Jayaram, E Deer… - Hypertension in …, 2020‏ - Taylor & Francis
The RUPP rat model of Preeclampsia exhibits hypertension (MAP), cytolytic natural killer
(cNK) cells, tumor necrosis factor alpha (TNF-α) and mitochondrial Reactive Oxygen …

Angiotensin II type 1 receptor agonistic autoantibody blockade improves postpartum hypertension and cardiac mitochondrial function in rat model of preeclampsia

GW Booz, D Kennedy, M Bowling, T Robinson… - Biology of sex …, 2021‏ - Springer
Women with preeclampsia (PE) have a greater risk of develo** hypertension,
cardiovascular disease (CVD), and renal disease later in life. Angiotensin II type I receptor …

Inhibiting B cell activating factor attenuates preeclamptic symptoms in placental ischemic rats

O Herrock, E Deer, LM Amaral… - American Journal of …, 2023‏ - Wiley Online Library
Abstract Problem Preeclampsia (PE), new‐onset hypertension during pregnancy, is
associated with a pro‐inflammatory state with activated T cells, cytolytic natural killer (NK) …