G-quadruplexes constitute a unique class of nucleic acid structures formed by G-rich
oligonucleotides of DNA-or RNA-type. Depending on their chemical nature, loops length …

First studies on thrombin-inhibiting DNA aptamers were reported in 1992, and since then a
large number of anticoagulant aptamers has been discovered. TBA–also named HD1, a 15 …

The thrombin binding aptamer (TBA) is a prototypical platform used to understand the impact
of chemically-modified nucleotides on aptamer stability and target affinity. To provide …

Thrombin-binding aptamer (TBA) is a DNA 15-mer of sequence 5′-GGT TGG TGT GGT
TGG-3′ that folds into a G-quadruplex structure linked by two TT loops located on one side …

Thrombin is a serine protease that plays a crucial role in hemostasis, fibrinolysis, cell
proliferation, and migration. Thrombin binding aptamer (TBA) is able to inhibit the activity of …

Thrombin plays a pivotal role in the coagulation cascade; therefore, it represents a primary
target in the treatment of several blood diseases. The 15‐mer DNA oligonucleotide 5 …

Progress in understanding and treatment of thrombotic diseases requires new effective
methods for the easy, rapid, and reversible control of coagulation processes. In this …

Despite their unquestionable properties, oligonucleotide aptamers display some drawbacks
that continue to hinder their applications. Several strategies have been undertaken to …

Human α-thrombin (TB) is a serine protease with a crucial role in coagulation and
hemostasis. The monitoring of the TB level in blood serum could be of great importance in …

Many antiproliferative G-quadruplexes (G4s) arise from the folding of GT-rich strands.
Among these, the Thrombin Binding Aptamer (TBA), as a rare example, adopts a …