Epidemiology and treatment of multiple sclerosis in elderly populations

CB Vaughn, D Jakimovski, KS Kavak… - Nature Reviews …, 2019 - nature.com
The prevalence of multiple sclerosis (MS) and the age of affected patients are increasing
owing to increased longevity of the general population and the availability of effective …

The role of Epstein-Barr virus in multiple sclerosis: from molecular pathophysiology to: in vivo: imaging

Y Guan, D Jakimovski, M Ramanathan… - Neural regeneration …, 2019 - journals.lww.com
Multiple sclerosis (MS) is a disease of the central nervous system characterized by
inflammation, demyelination, and neuronal damage. Environmental and genetic factors are …

Brain TSPO-PET predicts later disease progression independent of relapses in multiple sclerosis

M Sucksdorff, M Matilainen, J Tuisku, E Polvinen… - Brain, 2020 - academic.oup.com
Overactivation of microglia is associated with most neurodegenerative diseases. In this
study we examined whether PET-measurable innate immune cell activation predicts multiple …

Interferon β for multiple sclerosis

D Jakimovski, C Kolb… - Cold Spring …, 2018 - perspectivesinmedicine.cshlp.org
Despite that the availability of new therapeutic options has expanded the multiple sclerosis
(MS) disease-modifying therapy arsenal, interferon β (IFN-β) remains an important therapy …

“No evident disease activity”: the use of combined assessments in the management of patients with multiple sclerosis

G Giovannoni, D Tomic, JR Bright… - Multiple Sclerosis …, 2017 - journals.sagepub.com
Using combined endpoints to define no evident disease activity (NEDA) is becoming
increasingly common when setting targets for treatment outcomes in multiple sclerosis (MS) …

Multiple sclerosis in children: differential diagnosis, prognosis, and disease-modifying treatment

D Jakimovski, S Awan, SP Eckert, O Farooq… - CNS drugs, 2022 - Springer
Pediatric-onset multiple sclerosis (POMS) is a rare neuroinflammatory and
neurodegenerative disease that has a significant impact on long-term physical and cognitive …

Advances in brain imaging in multiple sclerosis

R Cortese, S Collorone, O Ciccarelli… - Therapeutic …, 2019 - journals.sagepub.com
Brain imaging is increasingly used to support clinicians in diagnosing multiple sclerosis
(MS) and monitoring its progression. However, the role of magnetic resonance imaging …

Serum neurofilament light chain level associations with clinical and cognitive performance in multiple sclerosis: A longitudinal retrospective 5-year study

D Jakimovski, R Zivadinov… - Multiple Sclerosis …, 2020 - journals.sagepub.com
Background: A limited number of studies investigated associations between serum
neurofilament light chain (sNfL) and cognition in persons with multiple sclerosis (PwMS) …

Neural stem cell transplantation in patients with progressive multiple sclerosis: an open-label, phase 1 study

A Genchi, E Brambilla, F Sangalli, M Radaelli… - Nature medicine, 2023 - nature.com
Innovative pro-regenerative treatment strategies for progressive multiple sclerosis (PMS),
combining neuroprotection and immunomodulation, represent an unmet need. Neural …

Late-onset MS: disease course and safety-efficacy of DMTS

MC Buscarinu, R Reniè, E Morena, C Romano… - Frontiers in …, 2022 - frontiersin.org
Multiple sclerosis (MS), an inflammatory demyelinating and neurodegenerative disease of
the central nervous system, usually begins between the ages of 20 and 49 years, though in …