Reversibility of hepatic fibrosis and cirrhosis following antiviral therapy for hepatitis B or C
has advanced the prospect of develo** antifibrotic therapies for patients with chronic liver …

Ghrelin, a gastric-derived acylated peptide, regulates energy homeostasis by transmitting
information about peripheral nutritional status to the brain, and is essential for protecting …

There have been considerable recent advances towards a better understanding of the
complex cellular and molecular network underlying liver fibrogenesis. Recent data indicate …

Cirrhosis is a chronic condition that can lead to liver failure. Currently, the viable option for
decreasing mortality is liver transplantation. However, transplant surgery is highly invasive …

Liver cirrhosis is frequently accompanied by disease-related malnutrition (DRM) and
sarcopenia, defined as loss of skeletal muscle mass and function. DRM and sarcopenia …

Fibrosis accumulation is a dynamic process resulting from a wound-healing response to
acute or chronic liver injury of all causes. The cascade starts with hepatocyte necrosis and …

Alcohol use disorder (AUD) remains a significant public health concern, affecting around 5%
of adults worldwide. Novel pathways of damage have been described during the last years …

Obesity, diabetes, insulin resistance, sedentary lifestyle, and Western diet are the key factors
underlying non-alcoholic fatty liver disease (NAFLD), one of the most common liver diseases …

The innate immune system represents the first-line response to invading microbes, tissue
damage, or aberrant cell growth. Many of the proteins and cells involved in innate immunity …

Background Growing evidence suggests the key role of ghrelin in the onset and progression
of nonalcoholic fatty liver disease (NAFLD). The potential participation of ghrelin and the …