Continuously rising trends in obesity-related malignancies render this disease spectrum a
public health priority. Worldwide, the burden of cancer attributable to obesity, expressed as …

In 2009, rapamycin was reported to increase the lifespan of mice when implemented later in
life. This observation resulted in a sea-change in how researchers viewed aging. This was …

Existing explanations of obesity-associated cancer emphasise direct mutagenic effects of
dietary components or hormonal imbalance. Some of these hypotheses are reviewed briefly …

Calorie restriction (CR) extends lifespan and has been shown to reduce age-related
diseases including cancer, diabetes, and cardiovascular and neurodegenerative diseases …

Background The role of dietary restriction regimens such as caloric restriction, ketogenic diet
and intermittent fasting in development of cancers has been detected via abundant …

Obesity is associated with a range of health outcomes that are of clinical and public health
significance, including cancer. Herein, we summarize epidemiologic and preclinical …

The way cancer cells utilize nutrients to support their growth and proliferation is determined
by cancer cell-intrinsic and cancer cell-extrinsic factors, including interactions with the …

The association of overweight/obesity with disease progression in patients with autosomal
dominant polycystic kidney disease (ADPKD) remains untested. We hypothesized that …

The epithelial-to-mesenchymal transition (EMT) is important for the development of cancer
metastases and organ fibrosis, conditions prevalent in aging. Because sirtuins affect the …

Numerous epidemiological and pre-clinical studies have demonstrated that the
insulin/insulin-like growth factor (IGF) system plays a key role in the development and …