Background Glutathione [GSH] is a major intracellular antioxidant that disposes peroxides
and protects neurons and glial cells from oxidative stress. In both schizophrenia and bipolar …

Abstract Purpose of Review Schizophrenia (SZ) is a debilitating mental illness; existing
treatments are partially effective and associated with significant side effect burden, largely …

Importance The use of high-field magnetic resonance spectroscopy (MRS) in multiple brain
regions of a large population of human participants facilitates in vivo study of localized or …

Abstract The Structured Interview for Psychosis-risk Syndromes (SIPS) has been one of most
commonly used instruments worldwide for diagnosing and evaluating subjects with a clinical …

Oxidative stress may contribute to declining course and poor outcomes in psychosis.
However, in vivo Magnetic Resonance Spectroscopy studies yield disparate results due to …

Glutathione (GSH) is an important antioxidant implicated in several physiological functions,
including the oxidation− reduction reaction balance and brain antioxidant defense against …

Abstract N-acetyl-aspartate (NAA) is a readily measured marker of neuronal metabolism.
Previous analyses in schizophrenia have shown NAA levels are low in frontal, temporal and …

Schizophrenia continues to be an illness with poor outcome. Most mechanistic changes
occur many years before the first episode of schizophrenia; these are not reversible after the …

Prefrontal cortex (PFC) inflammatory imbalance, oxidative/nitrosative stress (O/NS) and
impaired neuroplasticity in schizophrenia are thought to have neurodevelopmental origins …

Introduction Oxidative stress has been implicated in psychiatric disorders, including
posttraumatic stress disorder (PTSD). Currently, the status of glutathione (GSH), the brain's …