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[HTML][HTML] Biomarkers in cancer detection, diagnosis, and prognosis
Biomarkers are vital in healthcare as they provide valuable insights into disease diagnosis,
prognosis, treatment response, and personalized medicine. They serve as objective …
prognosis, treatment response, and personalized medicine. They serve as objective …
Spatial architecture of the immune microenvironment orchestrates tumor immunity and therapeutic response
Tumors are not only aggregates of malignant cells but also well-organized complex
ecosystems. The immunological components within tumors, termed the tumor immune …
ecosystems. The immunological components within tumors, termed the tumor immune …
Coordinated cellular neighborhoods orchestrate antitumoral immunity at the colorectal cancer invasive front
Antitumoral immunity requires organized, spatially nuanced interactions between
components of the immune tumor microenvironment (iTME). Understanding this coordinated …
components of the immune tumor microenvironment (iTME). Understanding this coordinated …
Predicting survival from colorectal cancer histology slides using deep learning: A retrospective multicenter study
Background For virtually every patient with colorectal cancer (CRC), hematoxylin–eosin
(HE)–stained tissue slides are available. These images contain quantitative information …
(HE)–stained tissue slides are available. These images contain quantitative information …
A review of cell-based computational modeling in cancer biology
Cancer biology involves complex, dynamic interactions between cancer cells and their
tissue microenvironments. Single-cell effects are critical drivers of clinical progression …
tissue microenvironments. Single-cell effects are critical drivers of clinical progression …
Regression-based Deep-Learning predicts molecular biomarkers from pathology slides
Deep Learning (DL) can predict biomarkers from cancer histopathology. Several clinically
approved applications use this technology. Most approaches, however, predict categorical …
approved applications use this technology. Most approaches, however, predict categorical …
Topography of cancer-associated immune cells in human solid tumors
Lymphoid and myeloid cells are abundant in the tumor microenvironment, can be quantified
by immunohistochemistry and shape the disease course of human solid tumors. Yet, there is …
by immunohistochemistry and shape the disease course of human solid tumors. Yet, there is …
The theory of tumor ecosystem
X Chen, E Song - Cancer Communications, 2022 - Wiley Online Library
Cancer cells can be conceived as “living organisms” interacting with cellular or non‐cellular
components in the host internal environment, not only the local tumor microenvironment but …
components in the host internal environment, not only the local tumor microenvironment but …
[HTML][HTML] Translating complexity and heterogeneity of pancreatic tumor: 3D in vitro to in vivo models
Pancreatic ductal adenocarcinoma (PDAC) is an extremely aggressive type of cancer with
an overall survival rate of less than 7-8%, emphasizing the need for novel effective …
an overall survival rate of less than 7-8%, emphasizing the need for novel effective …
Multiscale agent-based and hybrid modeling of the tumor immune microenvironment
Multiscale systems biology and systems pharmacology are powerful methodologies that are
playing increasingly important roles in understanding the fundamental mechanisms of …
playing increasingly important roles in understanding the fundamental mechanisms of …