Sulfonamide drugs: Structure, antibacterial property, toxicity, and biophysical interactions
A Ovung, J Bhattacharyya - Biophysical reviews, 2021 - Springer
Sulfonamide (or sulphonamide) functional group chemistry (SN) forms the basis of several
groups of drug. In vivo sulfonamides exhibit a range of pharmacological activities, such as …
groups of drug. In vivo sulfonamides exhibit a range of pharmacological activities, such as …
[HTML][HTML] Targeting matrix metalloproteinases in cancer: bringing new life to old ideas
J Cathcart, A Pulkoski-Gross, J Cao - Genes & diseases, 2015 - Elsevier
Since the identification of matrix metalloproteinases (MMPs), a family of zinc-dependent
endopeptidases, as being a driving factor for cancer progression and patient prognosis …
endopeptidases, as being a driving factor for cancer progression and patient prognosis …
Synthesis of sulfonamide and their synthetic and therapeutic applications: Recent advances
S Mondal, S Malakar - Tetrahedron, 2020 - Elsevier
A sulfonamide is a functional group that is the basis of several sulfa drugs and thereby are
very much important scaffolds in medicinal as well as in synthetic organic chemistry …
very much important scaffolds in medicinal as well as in synthetic organic chemistry …
Sulfa and trimethoprim-like drugs–antimetabolites acting as carbonic anhydrase, dihydropteroate synthase and dihydrofolate reductase inhibitors
Recent advances in microbial genomics, synthetic organic chemistry and X-ray
crystallography provided opportunities to identify novel antibacterial targets for the …
crystallography provided opportunities to identify novel antibacterial targets for the …
Bacterial, fungal and protozoan carbonic anhydrases as drug targets
Introduction: The carbonic anhydrases (CAs, EC 4.2. 1.1), a group of ubiquitously expressed
metalloenzymes, are involved in numerous physiological and pathological processes, as …
metalloenzymes, are involved in numerous physiological and pathological processes, as …
Structure, function and applications of carbonic anhydrase isozymes
The carbonic anhydrases enzymes (CAs, EC 4.2. 1.1) are zinc containing metalloproteins,
which efficiently catalyse the reversible conversion of carbon dioxide to bicarbonate and …
which efficiently catalyse the reversible conversion of carbon dioxide to bicarbonate and …
Vinyl sulfones: Synthetic preparations and medicinal chemistry applications
DC Meadows, J Gervay‐Hague - Medicinal research reviews, 2006 - Wiley Online Library
Vinyl sulfones have long been known for their synthetic utility in organic chemistry, easily
participating in 1, 4‐addition reactions and cycloaddition reactions. This functional group …
participating in 1, 4‐addition reactions and cycloaddition reactions. This functional group …
The development of BTK inhibitors: a five-year update
B Tasso, A Spallarossa, E Russo, C Brullo - Molecules, 2021 - mdpi.com
Bruton's tyrosine kinase (BTK) represented, in the past ten years, an important target for the
development of new therapeutic agents that could be useful for cancer and autoimmune …
development of new therapeutic agents that could be useful for cancer and autoimmune …
Pd-Catalyzed Conversion of Aryl Iodides to Sulfonyl Fluorides Using SO2 Surrogate DABSO and Selectfluor
AL Tribby, I Rodríguez, S Shariffudin… - The Journal of organic …, 2017 - ACS Publications
A one-pot Pd-catalyzed conversion of aryl iodide to aryl sulfonyl fluorides using DABSO and
Selectfluor has been developed generating aryl sulfonyl fluorides in good to excellent yields …
Selectfluor has been developed generating aryl sulfonyl fluorides in good to excellent yields …
Synthesis, Antimicrobial, Anti-Virulence and Anticancer Evaluation of New 5(4H)-Oxazolone-Based Sulfonamides
Since the synthesis of prontosil the first prodrug shares their chemical moiety, sulfonamides
exhibit diverse modes of actions to serve as antimicrobials, diuretics, antidiabetics, and other …
exhibit diverse modes of actions to serve as antimicrobials, diuretics, antidiabetics, and other …