Defining trained immunity and its role in health and disease
Immune memory is a defining feature of the acquired immune system, but activation of the
innate immune system can also result in enhanced responsiveness to subsequent triggers …
innate immune system can also result in enhanced responsiveness to subsequent triggers …
The intersecting pandemics of tuberculosis and COVID-19: population-level and patient-level impact, clinical presentation, and corrective interventions
The global tuberculosis burden remains substantial, with more than 10 million people newly
ill per year. Nevertheless, tuberculosis incidence has slowly declined over the past decade …
ill per year. Nevertheless, tuberculosis incidence has slowly declined over the past decade …
BCG vaccination protects against experimental viral infection in humans through the induction of cytokines associated with trained immunity
The tuberculosis vaccine bacillus Calmette-Guérin (BCG) has heterologous beneficial
effects against non-related infections. The basis of these effects has been poorly explored in …
effects against non-related infections. The basis of these effects has been poorly explored in …
[HTML][HTML] Non-specific effects of BCG vaccine on viral infections
S Moorlag, RJW Arts, R Van Crevel… - Clinical microbiology and …, 2019 - Elsevier
Abstract Background Some strains of Bacillus Calmette–Guérin (BCG) vaccine not only
confer protection against disseminated forms of tuberculosis, but also reduce all-cause …
confer protection against disseminated forms of tuberculosis, but also reduce all-cause …
Trained immunity: adaptation within innate immune mechanisms
J Domínguez-Andrés, JC Dos Santos… - Physiological …, 2023 - journals.physiology.org
The mechanisms underlying innate immune memory have been extensively explored in the
last decades but are in fact largely unknown. Although the specificity of adaptive immune …
last decades but are in fact largely unknown. Although the specificity of adaptive immune …
Nanotechnology-based ocular drug delivery systems: recent advances and future prospects
S Li, L Chen, Y Fu - Journal of Nanobiotechnology, 2023 - Springer
Ocular drug delivery has constantly challenged ophthalmologists and drug delivery
scientists due to various anatomical and physiological barriers. Static and dynamic ocular …
scientists due to various anatomical and physiological barriers. Static and dynamic ocular …
100 years of Bacillus Calmette–Guérin immunotherapy: from cattle to COVID-19
Abstract Bacillus Calmette–Guérin (BCG) is the most widely used vaccine worldwide and
has been used to prevent tuberculosis for a century. BCG also stimulates an anti-tumour …
has been used to prevent tuberculosis for a century. BCG also stimulates an anti-tumour …
Vaccinology: time to change the paradigm?
The existing vaccine paradigm assumes that vaccines only protect against the target
infection, that effective vaccines reduce mortality corresponding to the target infection's …
infection, that effective vaccines reduce mortality corresponding to the target infection's …
Inactivated trivalent influenza vaccination is associated with lower mortality among patients with COVID-19 in Brazil
Objective To estimate associations between trivalent influenza vaccination and COVID-19
mortality as well as severe clinical outcomes among hospitalised patients. Design …
mortality as well as severe clinical outcomes among hospitalised patients. Design …
SARS-CoV-2 rates in BCG-vaccinated and unvaccinated young adults
Discussion| Providing NIV in the prone position to patients with COVID-19 and ARDS on the
general wards in 1 hospital in Italy was feasible. The respiratory rate was lower and the …
general wards in 1 hospital in Italy was feasible. The respiratory rate was lower and the …