53BP1: A key player of DNA damage response with critical functions in cancer
Maintenance of genome integrity and stability is a critical responsibility of the DNA damage
response (DDR) within cells, such that any disruption in this kinase-based signaling …
response (DDR) within cells, such that any disruption in this kinase-based signaling …
Multifaceted regulation and functions of 53BP1 in NHEJ‑mediated DSB repair
T Lei, S Du, Z Peng, L Chen - … Journal of Molecular …, 2022 - spandidos-publications.com
The repair of DNA double‑strand breaks (DSBs) is crucial for the preservation of genomic
integrity and the maintenance of cellular homeostasis. Non‑homologous DNA end joining …
integrity and the maintenance of cellular homeostasis. Non‑homologous DNA end joining …
BRCA1-Mediated Dual Regulation of Ferroptosis Exposes a Vulnerability to GPX4 and PARP Co-Inhibition in BRCA1-Deficient Cancers
Resistance to poly (ADP-ribose) polymerase inhibitors (PARPi) limits the therapeutic efficacy
of PARP inhibition in treating breast cancer susceptibility gene 1 (BRCA1)-deficient cancers …
of PARP inhibition in treating breast cancer susceptibility gene 1 (BRCA1)-deficient cancers …
Drosha drives the formation of DNA: RNA hybrids around DNA break sites to facilitate DNA repair
The error-free and efficient repair of DNA double-stranded breaks (DSBs) is extremely
important for cell survival. RNA has been implicated in the resolution of DNA damage but the …
important for cell survival. RNA has been implicated in the resolution of DNA damage but the …
The CST complex mediates end protection at double-strand breaks and promotes PARP inhibitor sensitivity in BRCA1-deficient cells
M Barazas, S Annunziato, SJ Pettitt, I de Krijger… - Cell reports, 2018 - cell.com
Selective elimination of BRCA1-deficient cells by inhibitors of poly (ADP-ribose) polymerase
(PARP) is a prime example of the concept of synthetic lethality in cancer therapy. This …
(PARP) is a prime example of the concept of synthetic lethality in cancer therapy. This …
NRF2 preserves genomic integrity by facilitating ATR activation and G2 cell cycle arrest
X Sun, Y Wang, K Ji, Y Liu, Y Kong, S Nie… - Nucleic Acids …, 2020 - academic.oup.com
Nuclear factor erythroid 2-related factor 2 (NRF2) is a well-characterized transcription factor
that protects cells against oxidative and electrophilic stresses. Emerging evidence has …
that protects cells against oxidative and electrophilic stresses. Emerging evidence has …
MSCs inhibit tumor progression and enhance radiosensitivity of breast cancer cells by down-regulating Stat3 signaling pathway
N He, Y Kong, X Lei, Y Liu, J Wang, C Xu, Y Wang… - Cell death & …, 2018 - nature.com
The acquisition of radioresistance by breast cancer cells during radiotherapy may lead to
cancer recurrence and poor survival. Signal transducer and activator of transcription 3 …
cancer recurrence and poor survival. Signal transducer and activator of transcription 3 …
DNA repair mechanisms, protein interactions and therapeutic targeting of the MRN complex
C McCarthy-Leo, F Darwiche, MA Tainsky - Cancers, 2022 - mdpi.com
Simple Summary The MRN Complex (MRE11-RAD50-NBS1) is responsible for initiating
DNA double-strand break repair and activating several downstream proteins. These proteins …
DNA double-strand break repair and activating several downstream proteins. These proteins …
The chromatin landscape channels DNA double-strand breaks to distinct repair pathways
Z Chen, JK Tyler - Frontiers in Cell and Developmental Biology, 2022 - frontiersin.org
DNA double-strand breaks (DSBs), the most deleterious DNA lesions, are primarily repaired
by two pathways, namely homologous recombination (HR) and non-homologous end …
by two pathways, namely homologous recombination (HR) and non-homologous end …
Functional radiogenetic profiling implicates ERCC6L2 in non-homologous end joining
Using genome-wide radiogenetic profiling, we functionally dissect vulnerabilities of cancer
cells to ionizing radiation (IR). We identify ERCC6L2 as a major determinant of IR response …
cells to ionizing radiation (IR). We identify ERCC6L2 as a major determinant of IR response …