Post-translational modifications in proteins: resources, tools and prediction methods
Posttranslational modifications (PTMs) refer to amino acid side chain modification in some
proteins after their biosynthesis. There are more than 400 different types of PTMs affecting …
proteins after their biosynthesis. There are more than 400 different types of PTMs affecting …
Combining complex networks and data mining: why and how
The increasing power of computer technology does not dispense with the need to extract
meaningful information out of data sets of ever growing size, and indeed typically …
meaningful information out of data sets of ever growing size, and indeed typically …
Discerning molecular interactions: a comprehensive review on biomolecular interaction databases and network analysis tools
Computational analysis of biomolecular interaction networks is now gaining a lot of
importance to understand the functions of novel genes/proteins. Gene interaction (GI) …
importance to understand the functions of novel genes/proteins. Gene interaction (GI) …
Protein–protein interactions: detection, reliability assessment and applications
Protein–protein interactions (PPIs) participate in all important biological processes in living
organisms, such as catalyzing metabolic reactions, DNA replication, DNA transcription …
organisms, such as catalyzing metabolic reactions, DNA replication, DNA transcription …
New insights into protein–protein interaction modulators in drug discovery and therapeutic advance
Protein-protein interactions (PPIs) are fundamental to cellular signaling and transduction
which marks them as attractive therapeutic drug development targets. What were once …
which marks them as attractive therapeutic drug development targets. What were once …
Protein-protein interactions: Methods, databases, and applications in virus-host study
Almost all the cellular processes in a living system are controlled by proteins: They regulate
gene expression, catalyze chemical reactions, transport small molecules across …
gene expression, catalyze chemical reactions, transport small molecules across …
AlphaFold2 predicts whether proteins interact amidst confounding structural compatibility
Predicting whether two proteins physically interact is one of the holy grails of computational
biology, galvanized by rapid advancements in deep learning. AlphaFold2, although not …
biology, galvanized by rapid advancements in deep learning. AlphaFold2, although not …
Hub protein controversy: taking a closer look at plant stress response hubs
Plant stress responses involve numerous changes at the molecular and cellular level and
are regulated by highly complex signaling pathways. Studying protein-protein interactions …
are regulated by highly complex signaling pathways. Studying protein-protein interactions …
Efficient link prediction in the protein–protein interaction network using topological information in a generative adversarial network machine learning model
Background The investigation of possible interactions between two proteins in intracellular
signaling is an expensive and laborious procedure in the wet-lab, therefore, several in silico …
signaling is an expensive and laborious procedure in the wet-lab, therefore, several in silico …
SPRINT: ultrafast protein-protein interaction prediction of the entire human interactome
Background Proteins perform their functions usually by interacting with other proteins.
Predicting which proteins interact is a fundamental problem. Experimental methods are …
Predicting which proteins interact is a fundamental problem. Experimental methods are …