Oxidative stress (OxS) is considered a major factor in the pathophysiology of inflammatory
chronic liver diseases, including non-alcoholic liver disease (NAFLD). Chronic impairment of …

The transcription factor NRF2 is the master regulator of the cellular antioxidant response.
Though recognized originally as a target of chemopreventive compounds that help prevent …

NRF2 (Nuclear factor E2 p45‐related factor 2) is a stress responsive transcription factor
lending cells resilience against oxidative, xenobiotic, and also nutrient or proteotoxic insults …

Failed regeneration of myelin around neuronal axons following central nervous system
damage contributes to nerve dysfunction and clinical decline in various neurological …

Background No approved effective therapy for non-alcoholic steatohepatitis (NASH) is
currently available. Exosomes derived from mesenchymal stem cells (MSCs) perform the …

Hutchinson-Gilford progeria syndrome (HGPS) is a rare, invariably fatal premature aging
disorder. The disease is caused by constitutive production of progerin, a mutant form of the …

Obesity is a worldwide epidemic that predisposes individuals to many age-associated
diseases, but its exact effects on organ dysfunction are largely unknown. Hair follicles—mini …

Type 2 diabetes mellitus (DM) has reached pandemic proportions and effective prevention
strategies are wanted. Its onset is accompanied by cellular distress, the nuclear factor …

Laboratory animal models play an important role in the study of human diseases. Using
appropriate animals is critical not only for basic research but also for the development of …

Nonalcoholic fatty liver disease (NAFLD) is prevalent in the majority of individuals with
obesity, but in a subset of these individuals, it progresses to nonalcoholic steatohepatitis …