Basal forebrain cholinergic circuits and signaling in cognition and cognitive decline

EC Ballinger, M Ananth, DA Talmage, LW Role - Neuron, 2016 - cell.com
Recent work continues to place cholinergic circuits at center stage for normal executive and
mnemonic functioning and provides compelling evidence that the loss of cholinergic …

Cholinergic modulation of the hippocampal region and memory function

J Haam, JL Yakel - Journal of neurochemistry, 2017 - Wiley Online Library
Acetylcholine (AC h) plays an important role in memory function and has been implicated in
aging‐related dementia, in which the impairment of hippocampus‐dependent learning …

An improved neuroanatomical model of the default-mode network reconciles previous neuroimaging and neuropathological findings

PN Alves, C Foulon, V Karolis, D Bzdok… - Communications …, 2019 - nature.com
The brain is constituted of multiple networks of functionally correlated brain areas, out of
which the default-mode network (DMN) is the largest. Most existing research into the DMN …

Neuronal circuitry for recognition memory of object and place in rodent models

OY Chao, S Nikolaus, YM Yang, JP Huston - … & Biobehavioral Reviews, 2022 - Elsevier
Rats and mice are used for studying neuronal circuits underlying recognition memory due to
their ability to spontaneously remember the occurrence of an object, its place and an …

Cholinergic suppression of hippocampal sharp-wave ripples impairs working memory

Y Zhang, L Cao, V Varga, M **g… - Proceedings of the …, 2021 - National Acad Sciences
Learning and memory are assumed to be supported by mechanisms that involve cholinergic
transmission and hippocampal theta. Using G protein–coupled receptor-activation–based …

Specific basal forebrain–cortical cholinergic circuits coordinate cognitive operations

L Záborszky, P Gombkoto, P Varsanyi… - Journal of …, 2018 - Soc Neuroscience
Based on recent molecular genetics, as well as functional and quantitative anatomical
studies, the basal forebrain (BF) cholinergic projections, once viewed as a diffuse system …

Interneuronal mechanisms of hippocampal theta oscillations in a full-scale model of the rodent CA1 circuit

MJ Bezaire, I Raikov, K Burk, D Vyas, I Soltesz - Elife, 2016 - elifesciences.org
The hippocampal theta rhythm plays important roles in information processing; however, the
mechanisms of its generation are not well understood. We developed a data-driven …

[HTML][HTML] Acetylcholine bidirectionally regulates learning and memory

Q Huang, C Liao, F Ge, J Ao, T Liu - Journal of Neurorestoratology, 2022 - Elsevier
Acetylcholine (ACh) is one of the most important neurotransmitters in the central cholinergic
system; it specifically binds to muscarinic and nicotinic receptors and is degraded by …

Molecularly defined and functionally distinct cholinergic subnetworks

X Li, H Yu, B Zhang, L Li, W Chen, Q Yu, X Huang… - Neuron, 2022 - cell.com
Cholinergic neurons in the medial septum (MS) constitute a major source of cholinergic
input to the forebrain and modulate diverse functions, including sensory processing …

Supramammillary regulation of locomotion and hippocampal activity

JS Farrell, M Lovett-Barron, PM Klein, FT Sparks… - Science, 2021 - science.org
Locomotor speed is a basic input used to calculate one's position, but where this signal
comes from is unclear. We identified neurons in the supramammillary nucleus (SuM) of the …