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Fibrinogen and fibrin: synthesis, structure, and function in health and disease
AS Wolberg - Journal of Thrombosis and Haemostasis, 2023 - Elsevier
Fibrinogen is an extraordinary molecule by any estimation. It is large, structurally intricate,
and circulates at high concentrations. Its biological end product, insoluble fibrin (ogen) or …
and circulates at high concentrations. Its biological end product, insoluble fibrin (ogen) or …
Fibrin clot structure and function: a role in the pathophysiology of arterial and venous thromboembolic diseases
The formation of fibrin clots that are relatively resistant to lysis represents the final step in
blood coagulation. We discuss the genetic and environmental regulators of fibrin structure in …
blood coagulation. We discuss the genetic and environmental regulators of fibrin structure in …
Factor XIII: a coagulation factor with multiple plasmatic and cellular functions
Factor XIII (FXIII) is unique among clotting factors for a number of reasons: 1) it is a
protransglutaminase, which becomes activated in the last stage of coagulation; 2) it works …
protransglutaminase, which becomes activated in the last stage of coagulation; 2) it works …
Fibrinogen and factor XIII in venous thrombosis and thrombus stability
AS Wolberg, Y Sang - Arteriosclerosis, thrombosis, and vascular …, 2022 - ahajournals.org
As the third most common vascular disease, venous thromboembolism is associated with
significant mortality and morbidity. Pathogenesis underlying venous thrombosis is still not …
significant mortality and morbidity. Pathogenesis underlying venous thrombosis is still not …
Structure of fibrin: impact on clot stability
Information on the structural origins of clot stability is necessary for understanding the
functions and pathology of fibrin clots and thrombi, but is also important for interpreting …
functions and pathology of fibrin clots and thrombi, but is also important for interpreting …
Directing thrombin
Following initiation of coagulation as part of the hemostatic response to injury, thrombin is
generated from its inactive precursor prothrombin by factor Xa as part of the prothrombinase …
generated from its inactive precursor prothrombin by factor Xa as part of the prothrombinase …
Factor XIII activity mediates red blood cell retention in venous thrombi
Venous thrombi, fibrin-and rbc-rich clots triggered by inflammation and blood stasis, underlie
devastating, and sometimes fatal, occlusive events. During intravascular fibrin deposition …
devastating, and sometimes fatal, occlusive events. During intravascular fibrin deposition …
Transglutaminases and disease: lessons from genetically engineered mouse models and inherited disorders
The human transglutaminase (TG) family consists of a structural protein, protein 4.2, that
lacks catalytic activity, and eight zymogens/enzymes, designated factor XIII-A (FXIII-A) and …
lacks catalytic activity, and eight zymogens/enzymes, designated factor XIII-A (FXIII-A) and …
Role of factor XIII in fibrin clot formation and effects of genetic polymorphisms
Factor XIII and fibrinogen are unusual among clotting factors in that neither is a serine
protease. Fibrin is the main protein constituent of the blood clot, which is stabilized by factor …
protease. Fibrin is the main protein constituent of the blood clot, which is stabilized by factor …
Genetic risk factors of venous thrombosis
Venous thrombosis, whose main clinical presentations include deep vein thrombosis and
pulmonary embolism, represents a major health problem worldwide. Numerous conditions …
pulmonary embolism, represents a major health problem worldwide. Numerous conditions …