Ewing sarcoma—diagnosis, treatment, clinical challenges and future perspectives
Ewing sarcoma, a highly aggressive bone and soft-tissue cancer, is considered a prime
example of the paradigms of a translocation-positive sarcoma: a genetically rather simple …
example of the paradigms of a translocation-positive sarcoma: a genetically rather simple …
Ewing's sarcoma
N Riggi, ML Suvà, I Stamenkovic - New England Journal of …, 2021 - Mass Medical Soc
Ewing's Sarcoma Ewing's sarcoma, an aggressive cancer of bone and soft tissue, primarily
affects children and young adults. A t (11; 22) translocation is noted in 85 to 90% of cases …
affects children and young adults. A t (11; 22) translocation is noted in 85 to 90% of cases …
EWSR1-induced circNEIL3 promotes glioma progression and exosome-mediated macrophage immunosuppressive polarization via stabilizing IGF2BP3
Z Pan, R Zhao, B Li, Y Qi, W Qiu, Q Guo, S Zhang… - Molecular cancer, 2022 - Springer
Background Gliomas are the most common malignant primary brain tumours with a highly
immunosuppressive tumour microenvironment (TME) and poor prognosis. Circular RNAs …
immunosuppressive tumour microenvironment (TME) and poor prognosis. Circular RNAs …
TRIM8 modulates the EWS/FLI oncoprotein to promote survival in Ewing sarcoma
Fusion-transcription factors (fusion-TFs) represent a class of driver oncoproteins that are
difficult to therapeutically target. Recently, protein degradation has emerged as a strategy to …
difficult to therapeutically target. Recently, protein degradation has emerged as a strategy to …
Hypergraph geometry reflects higher-order dynamics in protein interaction networks
Protein interactions form a complex dynamic molecular system that shapes cell phenotype
and function; in this regard, network analysis is a powerful tool for studying the dynamics of …
and function; in this regard, network analysis is a powerful tool for studying the dynamics of …
[HTML][HTML] STAG2 loss rewires oncogenic and developmental programs to promote metastasis in Ewing sarcoma
The core cohesin subunit STAG2 is recurrently mutated in Ewing sarcoma but its biological
role is less clear. Here, we demonstrate that cohesin complexes containing STAG2 occupy …
role is less clear. Here, we demonstrate that cohesin complexes containing STAG2 occupy …
STAG2 mutations alter CTCF-anchored loop extrusion, reduce cis-regulatory interactions and EWSR1-FLI1 activity in Ewing sarcoma
D Surdez, S Zaidi, S Grossetête, K Laud-Duval… - Cancer cell, 2021 - cell.com
STAG2, a cohesin family gene, is among the most recurrently mutated genes in cancer.
STAG2 loss of function (LOF) is associated with aggressive behavior in Ewing sarcoma, a …
STAG2 loss of function (LOF) is associated with aggressive behavior in Ewing sarcoma, a …
The YAP/TAZ pathway in osteogenesis and bone sarcoma pathogenesis
YAP and TAZ are intracellular messengers communicating multiple interacting extracellular
biophysical and biochemical cues to the transcription apparatus in the nucleus and back to …
biophysical and biochemical cues to the transcription apparatus in the nucleus and back to …
Independent component analysis for unraveling the complexity of cancer omics datasets
Independent component analysis (ICA) is a matrix factorization approach where the signals
captured by each individual matrix factors are optimized to become as mutually independent …
captured by each individual matrix factors are optimized to become as mutually independent …
Unraveling Ewing sarcoma tumorigenesis originating from patient-derived mesenchymal stem cells
A Sole, S Grossetête, M Heintzé, L Babin, S Zaïdi… - Cancer research, 2021 - AACR
Ewing sarcoma is characterized by pathognomonic translocations, most frequently fusing
EWSR1 with FLI1. An estimated 30% of Ewing sarcoma tumors also display genetic …
EWSR1 with FLI1. An estimated 30% of Ewing sarcoma tumors also display genetic …