For hundreds of years, mankind has been influencing its sleep and waking state through the
adenosinergic system. For~ 100 years now, systematic research has been performed, first …

The inverse effects of creatine supplementation and sleep deprivation on high energy
phosphates, neural creatine, and cognitive performances suggest that creatine is a suitable …

Pain disrupts sleep, and sleep deprivation or interference can alter pain perception in
animals and humans, for example by increasing sensitivity to pain. However, the mechanism …

Abstract Aim Modified Suanzaoren Decoction (MSZRD) is obtained by improving
Suanzaoren Decoction (SZRT), a traditional Chinese herbal prescription that has been used …

Sleep-wake driven changes in non-rapid-eye-movement sleep (NREM) sleep (NREMS)
EEG delta (δ-) power are widely used as proxy for a sleep homeostatic process. Here, we …

Sleep loss pervasively affects the human brain at multiple levels. Age-related changes in
several sleep characteristics indicate that reduced sleep quality is a frequent characteristic …

Ethnopharmacological relevance Insomnia occurs frequently in modern society, and its
common symptoms include difficulty in falling asleep and decreased sleep quality and time …

Hybrid imaging using PET/MRI has emerged as a platform for elucidating novel
neurobiology, molecular and functional changes in disease, and responses to physiological …

On average, humans spend about 26 years of their life slee**. Increased sleep duration
and quality has been linked to reduced disease risk; however, the cellular and molecular …

Sleep inertia is a disabling state of grogginess and impaired vigilance immediately upon
awakening. The adenosine receptor antagonist, caffeine, is widely used to reduce sleep …