Insulin resistance is the pivotal pathogenic component of many metabolic diseases,
including type 2 diabetes mellitus, and is defined as a state of reduced responsiveness of …

Excess intra-abdominal adipose tissue accumulation, often termed visceral obesity, is part of
a phenotype including dysfunctional subcutaneous adipose tissue expansion and ectopic …

Adipose tissue exhibits remarkable plasticity with capacity to change in size and cellular
composition under physiological and pathophysiological conditions. The emergence of …

Obesity is recognized as a heterogeneous condition in which individuals with similar body
mass index may have distinct metabolic and cardiovascular risk profiles. Susceptibility to …

The ability to efficiently adapt metabolism by substrate sensing, trafficking, storage, and
utilization, dependent on availability and requirement, is known as metabolic flexibility. In …

Glucagon-like peptide-1 (GLP-1) receptor agonists improve glucose homeostasis, reduce
bodyweight, and over time benefit cardiovascular health in type 2 diabetes mellitus (T2DM) …

While the link between obesity and type 2 diabetes is clear on an epidemiological level, the
underlying mechanism linking these two common disorders is not as clearly understood …

Although abnormal glucose metabolism defines type 2 diabetes mellitus (T2DM) and
accounts for many of its symptoms and complications, efforts to understand the …

The major effects of insulin on muscle and adipose tissue are:(1) Carbohydrate
metabolism:(a) it increases the rate of glucose transport across the cell membrane,(b) it …

The pathology of type 2 diabetes is complex, with multiple stages culminating in a functional
β‐cell mass that is insufficient to meet the body's needs. Although the broad outlines of the …