Insulin resistance is the pivotal pathogenic component of many metabolic diseases,
including type 2 diabetes mellitus, and is defined as a state of reduced responsiveness of …

The prevalence of obesity and associated chronic diseases continues to increase
worldwide, negatively impacting on societies and economies. Whereas the association …

Emotional well-being, an individual‟ s subjective feelings of happiness, satisfied social
relationships and self-contentment, is necessary for successful ageing. However, reports …

Adipose tissue exhibits remarkable plasticity with capacity to change in size and cellular
composition under physiological and pathophysiological conditions. The emergence of …

Glucagon-like peptide-1 (GLP-1) receptor agonists improve glucose homeostasis, reduce
bodyweight, and over time benefit cardiovascular health in type 2 diabetes mellitus (T2DM) …

Obesity is recognized as a heterogeneous condition in which individuals with similar body
mass index may have distinct metabolic and cardiovascular risk profiles. Susceptibility to …

The ability to efficiently adapt metabolism by substrate sensing, trafficking, storage, and
utilization, dependent on availability and requirement, is known as metabolic flexibility. In …

Tirzepatide (LY3298176), a dual GIP and GLP-1 receptor (GLP-1R) agonist, delivered
superior glycemic control and weight loss compared with GLP-1R agonism in patients with …

Like the obesity epidemic, our understanding of adipocytes and adipose tissue is
expanding. Just in the past decade, substantial advances have led to new insights into the …

Resistance to insulin is a pathophysiological state related to the decreased response of
peripheral tissues to the insulin action, hyperinsulinemia and raised blood glucose levels …