Genomewide association studies in pharmacogenomics
The increasing availability of genotype data linked with information about drug‐response
phenotypes has enabled genomewide association studies (GWAS) that uncover genetic …
phenotypes has enabled genomewide association studies (GWAS) that uncover genetic …
Pharmacogenomics for primary care: an overview
V Rollinson, R Turner, M Pirmohamed - Genes, 2020 - mdpi.com
Most of the prescribing and dispensing of medicines happens in primary care.
Pharmacogenomics (PGx) is the study and clinical application of the role of genetic variation …
Pharmacogenomics (PGx) is the study and clinical application of the role of genetic variation …
Race influences warfarin dose changes associated with genetic factors
Warfarin dosing algorithms adjust for race, assigning a fixed effect size to each predictor,
thereby attenuating the differential effect by race. Attenuation likely occurs in both race …
thereby attenuating the differential effect by race. Attenuation likely occurs in both race …
Oral anticoagulation: a critique of recent advances and controversies
There have recently been significant advances in the field of oral anticoagulation, but these
have also led to many controversies. Warfarin is still the commonest drug used for clotting …
have also led to many controversies. Warfarin is still the commonest drug used for clotting …
Analytical validation of GenoPharm a clinical genoty** open array panel of 46 pharmacogenes inclusive of variants unique to people of African ancestry
Pharmacogenomic testing may be used to improve treatment outcomes and reduce the
frequency of adverse drug reactions (ADRs). Population specific, targeted …
frequency of adverse drug reactions (ADRs). Population specific, targeted …
Translational pharmacogenomics: discovery, evidence synthesis and delivery of race‐conscious medicine
Response to medications, the principal treatment modality for acute and chronic diseases, is
highly variable, with 40–70% of patients exhibiting lack of efficacy or adverse drug reactions …
highly variable, with 40–70% of patients exhibiting lack of efficacy or adverse drug reactions …
Cracking the code of human diseases using next‐generation sequencing: Applications, challenges, and perspectives
V Precone, V Del Monaco, MV Esposito… - BioMed research …, 2015 - Wiley Online Library
Next‐generation sequencing (NGS) technologies have greatly impacted on every field of
molecular research mainly because they reduce costs and increase throughput of DNA …
molecular research mainly because they reduce costs and increase throughput of DNA …
Folylpoly-γ-glutamate synthetase: a key determinant of folate homeostasis and antifolate resistance in cancer
Mammalians are devoid of autonomous biosynthesis of folates and hence must obtain them
from the diet. Reduced folate cofactors are B9-vitamins which play a key role as donors of …
from the diet. Reduced folate cofactors are B9-vitamins which play a key role as donors of …
Working toward precision medicine: Predicting phenotypes from exomes in the Critical Assessment of Genome Interpretation (CAGI) challenges
Precision medicine aims to predict a patient's disease risk and best therapeutic options by
using that individual's genetic sequencing data. The Critical Assessment of Genome …
using that individual's genetic sequencing data. The Critical Assessment of Genome …
Identifying core biological processes distinguishing human eye tissues with precise systems-level gene expression analyses and weighted correlation networks
The human eye is built from several specialized tissues which direct, capture and pre-
process information to provide vision. The gene expression of the different eye tissues has …
process information to provide vision. The gene expression of the different eye tissues has …