Drug resistance in epilepsy: clinical impact, potential mechanisms, and new innovative treatment options

W Löscher, H Potschka, SM Sisodiya… - Pharmacological reviews, 2020 - Elsevier
Epilepsy is a chronic neurologic disorder that affects over 70 million people worldwide.
Despite the availability of over 20 antiseizure drugs (ASDs) for symptomatic treatment of …

Towards network-guided neuromodulation for epilepsy

RJ Piper, RM Richardson, G Worrell, DW Carmichael… - Brain, 2022 - academic.oup.com
Epilepsy is well-recognized as a disorder of brain networks. There is a growing body of
research to identify critical nodes within dynamic epileptic networks with the aim to target …

[HTML][HTML] Mechanisms of drug resistance in the pathogenesis of epilepsy: role of neuroinflammation. A literature review

ED Bazhanova, AA Kozlov, AV Litovchenko - Brain sciences, 2021 - mdpi.com
Epilepsy is a chronic neurological disorder characterized by recurring spontaneous
seizures. Drug resistance appears in 30% of patients and it can lead to premature death …

Connectome biomarkers of drug‐resistant epilepsy

S Larivière, A Bernasconi, N Bernasconi… - …, 2021 - Wiley Online Library
Drug‐resistant epilepsy (DRE) considerably affects patient health, cognition, and well‐
being, and disproportionally contributes to the overall burden of epilepsy. The most common …

Lateralization of the hippocampus: a review of molecular, functional, and physiological properties in health and disease

SS Nemati, L Sadeghi, G Dehghan… - Behavioural Brain …, 2023 - Elsevier
The hippocampus is a part of the brain's medial temporal lobe that is located under the
cortex. It belongs to the limbic system and helps to collect and transfer information from short …

Resective surgery prevents progressive cortical thinning in temporal lobe epilepsy

M Galovic, J de Tisi, AW McEvoy, A Miserocchi, SB Vos… - Brain, 2020 - academic.oup.com
Focal epilepsy in adults is associated with progressive atrophy of the cortex at a rate more
than double that of normal ageing. We aimed to determine whether successful epilepsy …

Optimal surgical extent for memory and seizure outcome in temporal lobe epilepsy

D Sone, M Ahmad, PJ Thompson… - Annals of …, 2022 - Wiley Online Library
Objective Postoperative memory decline is an important consequence of anterior temporal
lobe resection (ATLR) for temporal lobe epilepsy (TLE), and the extent of resection may be a …

Automatic and manual segmentation of the piriform cortex: Method development and validation in patients with temporal lobe epilepsy and Alzheimer's disease

D Steinbart, SN Yaakub, M Steinbrenner… - Human Brain …, 2023 - Wiley Online Library
The piriform cortex (PC) is located at the junction of the temporal and frontal lobes. It is
involved physiologically in olfaction as well as memory and plays an important role in …

Assessment of direct knowledge of the human olfactory system

G Lane, G Zhou, T Noto, C Zelano - Experimental neurology, 2020 - Elsevier
The olfactory system is highly conserved across mammalian species (Ache and Young,
2005; Gelperin, 1999; Hildebrand and Shepherd, 1997; Laurent, 2002). In particular, the …

[HTML][HTML] The connectivity-based architecture of the human piriform cortex

F Zahnert, U Kleinholdermann, M Belke, B Keil… - NeuroImage, 2024 - Elsevier
The anatomy of the human piriform cortex (PC) is poorly understood. We used a bimodal
connectivity-based-parcellation approach to investigate subregions of the PC and its …