Bacterial natural products (BNPs) are very important sources of leads for drug development
and chemical novelty. The possibility to perform late-stage diversification of BNPs using …

This is a review of papers published in the year 2009 that focus on the synthesis, reactivity,
or properties of compounds containing a carbon-transition metal double or triple bond.

Challenging Ru-catalyzed ring-closing metathesis transformations leading to eight-
membered-ring systems and Ni-or Co-catalyzed [2+ 2+ 2] cyclotrimerizations were …

A novel antifungal strategy targeting the inhibition of calcineurin is described. To develop a
calcineurin based inhibitor of pathogenic fungi, analogs of FK506 were synthesized that …

Alzheimer's disease (AD) is characterized by the self-assembly of amyloid beta (Aβ)
peptides. Recent models implicate some of the earliest Aβ oligomers, such as trimers and …

Epstein-Barr virus (EBV) is a ubiquitous human gammaherpesvirus that establishes a
latency reservoir in B cells. In this work, we show that ibrutinib, idelalisib, and dasatinib …

This chapter focuses on cross‐metathesis applications and surveys the literature between
2003 and 2013, highlighting examples from more than 480 papers. After a brief historical …

This chapter is devoted to olefin cross metathesis (CM), which is represented in the
equation. It focuses only on the alkene variant of CM. The chapter introduces another …

An efficient one-step functionalization of FK506 by the thiol–ene click (TEC) reaction is
reported. This approach, which enables rapid and quantitative generation of bioactive …

Olefin cross metathesis on solid support under a variety of conditions is described. A
comprehensive analysis considering diverse factors governing the reaction outcome gives a …