Nuclear speckles are dynamic membraneless bodies located in the cell nucleus. They
harbor RNAs and proteins, many of which are splicing factors, that together display complex …

Proteins with motifs rich in arginines and glycines were discovered decades ago and are
functionally involved in a staggering range of essential processes in the cell. Versatile …

Multiple coronaviruses have emerged independently in the past 20 years that cause lethal
human diseases. Although vaccine development targeting these viruses has been …

Circular RNAs (circRNAs) are a recently rediscovered class of functional noncoding RNAs
that are involved in gene regulation and cancer development. Next-generation sequencing …

Osteoarthritis is the most common joint disorder. However, there are no disease-modifying
drugs approved for OA treatment. CDC2-like kinase 2 (CLK2) could modulate Wnt signaling …

While vaccines are vital for preventing COVID-19 infections, it is critical to develop new
therapies to treat patients who become infected. Pharmacological targeting of a host factor …

Protein phosphorylation constitutes a major post-translational modification that critically
regulates the half-life, intra-cellular distribution, and activity of proteins. Among the large …

Background Host shutoff refers to the widespread downregulation of host gene expression
and has emerged as a key process that facilitates the reallocation of cellular resources for …

Throughout the viral life cycle, interplays between cellular host factors and virus determine
the infectious capacity of the virus. The pandemic of coronavirus disease 2019 (COVID-19) …

During lytic infection, herpes simplex virus (HSV) 1 induces a rapid shutoff of host RNA
synthesis while redirecting transcriptional machinery to viral genes. In addition to being a …