The last 10 years witnessed an acceleration of our understanding of what genetic factors
underpin the risk of breast cancer. Rare high-and moderate-penetrance variants such as …

Cancer genome sequencing methods have now become essential for diagnostic purposes,
for devising treatment strategies, and for monitoring disease regression and progression …

Genetic diversity of germline variants in breast cancer (BC) predisposition genes is
unexplored in miscegenated populations, such those living in Latin America. We evaluated …

PURPOSE To report on pathogenic germline variants detected among individuals
undergoing genetic testing for hereditary breast and/or ovarian cancer (HBOC) from Latin …

PURPOSE The objective of this review was to address the barriers limiting access to genetic
cancer risk assessment and genetic testing for individuals with suspected hereditary breast …

Brazil is the largest country in South America and the most genetically heterogeneous. The
aim of the present study was to determine the prevalence of germline pathogenic variants …

Background: Precision oncology has been increasingly used in clinical practice and rapidly
evolving in the oncology field. Thus, this study was performed to assess the frequency of …

Simple Summary Breast cancer (BC) has common characteristics in women and female
dogs, such as high recurrence, metastasis, and mortality rate. In both species, BC prognosis …

Purpose Knowledge about the germline mutational spectrum among Brazilian with
hereditary breast and ovarian cancer (HBOC) is limited. Only five studies have performed …

Latin American populations, characterized by intricate admixture patterns resulting from the
intermingling of ancestries from European, Native American (NA) Asian, and African …