Although most autoimmune diseases are considered to be CD4 T cell-or antibody-mediated,
many respond to CD20-depleting antibodies that have limited influence on CD4 and plasma …

The adaptive immune system and associated inflammation are vital in surveillance and host
protection against internal and external threats, but can secondarily damage host tissues …

Ocrelizumab (Ocrevus®) is an intravenously administered, humanized anti-CD20
monoclonal antibody approved for the treatment of adults with relapsing forms of multiple …

There are> 18 distinct disease-modifying therapy (DMT) options covering 10 mechanisms of
action currently approved by the US Food and Drug Administration for the treatment of …

Monoclonal antibodies that target CD20 expressing B cells represent an important new
treatment option for patients with multiple sclerosis (MS). B‐cell‐depleting therapy is highly …

Autoimmune diseases are a group of serious immune system disorders that are usually
idiopathic and persistent. Currently, autoimmune diseases are often diagnosed after obvious …

The cause and the pathogenic mechanisms leading to multiple sclerosis (MS), a chronic
inflammatory disease of the central nervous system (CNS), are still under scrutiny. During …

Immune Tolerance The immune system distinguishes between “self” and “nonself” and
remembers dangerous exposures. Elaborate mechanisms control immune responses, but in …

Background SARS-CoV-2 viral infection causes COVID-19 that can result in severe acute
respiratory distress syndrome (ARDS), which can cause significant mortality, leading to …

Autoimmunity plays a significant role in the pathogenesis of demyelination. Multiple
sclerosis (MS), neuromyelitis optica spectrum disorders (NMOSD) and myelin …