Vertebrate oocytes face a particular challenge concerning the regulation of gene expression
during meiotic maturation. Global transcription becomes quiescent in fully grown oocytes …

Transcriptional and post-transcriptional regulations control gene expression in most cells.
However, critical transitions during the development of the female gamete relies exclusively …

Embryo development depends upon maternally derived materials. Mammalian oocytes
undergo extreme asymmetric cytokinesis events, producing one large egg and two small …

Meiotic maturation is an intricate and precisely regulated process orchestrated by various
pathways and numerous proteins. However, little is known about the proteome landscape …

RNA—the primary product of the genome—is subject to various biological events during its
lifetime. During mammalian gametogenesis and early embryogenesis, germ cells and …

Translation of maternal mRNAs is detected before transcription of zygotic genes and is
essential for mammalian embryo development. How certain maternal mRNAs are selected …

The oocyte transcriptome follows a tightly controlled dynamic that leads the oocyte to grow
and mature. This succession of distinct transcriptional states determines embryonic …

In somatic cells, RNA polymerase II (Pol II) transcription initiation starts by the binding of the
general transcription factor TFIID, containing the TATA-binding protein (TBP) and 13 TBP …

During oocyte development in mice, transcripts accumulate in the growth phase and are
subsequently degraded during maturation. At the transition point between growth and …

MicroRNAs (miRNAs) are ubiquitous small RNAs guiding post-transcriptional gene
repression in countless biological processes. However, the miRNA pathway in mouse …