Immune-based classification of HPV-associated oropharyngeal cancer with implications for biomarker-driven treatment de-intensification
Background There is significant interest in treatment de-escalation for human papillomavirus-
associated (HPV+) oropharyngeal squamous cell carcinoma (OPSCC) patients given the …
associated (HPV+) oropharyngeal squamous cell carcinoma (OPSCC) patients given the …
Targeted therapy as a potential de-escalation strategy in locally advanced HPV-associated oropharyngeal cancer: a literature review
L Chitsike, PJ Duerksen-Hughes - Frontiers in Oncology, 2021 - frontiersin.org
The treatment landscape of locally advanced HPV-oropharyngeal squamous cell carcinoma
(OPSCC) is undergoing transformation. This is because the high cures rates observed in …
(OPSCC) is undergoing transformation. This is because the high cures rates observed in …
Survival-associated metabolic genes in human papillomavirus-positive head and neck cancers
Human papillomavirus (HPV) causes an increasing number of head and neck squamous
cell carcinomas (HNSCCs). Altered metabolism contributes to patient prognosis, but the …
cell carcinomas (HNSCCs). Altered metabolism contributes to patient prognosis, but the …
FOXM1 drives HPV+ HNSCC sensitivity to WEE1 inhibition
A Diab, H Gem, J Swanger, HY Kim… - Proceedings of the …, 2020 - National Acad Sciences
Head and neck squamous cell carcinoma (HNSCC) associated with high-risk human
papilloma virus (HPV) infection is a growing clinical problem. The WEE1 kinase inhibitor …
papilloma virus (HPV) infection is a growing clinical problem. The WEE1 kinase inhibitor …
EGFR and PI3K pathway activities might guide drug repurposing in HPV-negative head and neck cancers
A Mock, M Plath, J Moratin, MJ Tapken, D Jäger… - Frontiers in …, 2021 - frontiersin.org
While genetic alterations in Epidermal growth factor receptor (EGFR) and PI3K are common
in head and neck squamous cell carcinomas (HNSCC), their impact on oncogenic signaling …
in head and neck squamous cell carcinomas (HNSCC), their impact on oncogenic signaling …
ERK-TSC2 signalling in constitutively-active HRAS mutant HNSCC cells promotes resistance to PI3K inhibition
Abstract Objectives The PI3K/AKT/mTOR pathway is frequently altered in head and neck
squamous cell cancer (HNSCC), making this pathway a logical therapeutic target. However …
squamous cell cancer (HNSCC), making this pathway a logical therapeutic target. However …
All HPV-negative head and neck cancers are not the same: Analysis of the TCGA dataset reveals that anatomical sites have distinct mutation, transcriptome, hypoxia …
Purpose Head and neck squamous cell carcinoma (HNSCC) affects various anatomical
sites, which often dictates whether the cancer is managed with primary surgery or radiation …
sites, which often dictates whether the cancer is managed with primary surgery or radiation …
A review on kinases phosphorylating the carboxyl-terminal domain of RNA polymerase II—Biological functions and inhibitors
J Zhang, X Zhang, H Huang, Y Ding - Bioorganic Chemistry, 2020 - Elsevier
Abstract RNA polymerase II (RNA Pol II) plays a major role in gene transcription for
eukaryote. One of the major modes of regulation in eukaryotes is the phosphorylation of the …
eukaryote. One of the major modes of regulation in eukaryotes is the phosphorylation of the …
Uncovering drug repurposing candidates for head and neck cancers: insights from systematic pharmacogenomics data analysis
Effective treatment options for head and neck squamous cell carcinoma (HNSCC) are
currently lacking. We exploited the drug response and genomic data of the 28 HNSCC cell …
currently lacking. We exploited the drug response and genomic data of the 28 HNSCC cell …
TAM family receptors in conjunction with MAPK signalling are involved in acquired resistance to PI3Kα inhibition in head and neck squamous cell carcinoma
KM Ruicci, J Meens, P Plantinga, W Stecho… - Journal of Experimental …, 2020 - Springer
Background Aberrant activation of the phosphatidylinositol 3-kinase (PI3K) pathway is
common in many malignancies, including head and neck squamous cell carcinoma …
common in many malignancies, including head and neck squamous cell carcinoma …