[HTML][HTML] Neuropathic pain: from mechanisms to treatment

NB Finnerup, R Kuner, TS Jensen - Physiological reviews, 2020 - journals.physiology.org
Neuropathic pain caused by a lesion or disease of the somatosensory nervous system is a
common chronic pain condition with major impact on quality of life. Examples include …

Intervertebral disc degeneration and osteoarthritis: a common molecular disease spectrum

N Fine, S Lively, CA Séguin, AV Perruccio… - Nature Reviews …, 2023 - nature.com
Intervertebral disc degeneration (IDD) and osteoarthritis (OA) affecting the facet joint of the
spine are biomechanically interdependent, typically occur in tandem, and have considerable …

Revealing the immune infiltration landscape and identifying diagnostic biomarkers for lumbar disc herniation

L Wang, T He, J Liu, J Tai, B Wang, L Zhang… - Frontiers in …, 2021 - frontiersin.org
Intervertebral disc (IVD) degeneration and its inflammatory microenvironment ultimately led
to discogenic pain, which is thought to originate in the nucleus pulposus (NP). In this study …

[HTML][HTML] Cellular senescence–molecular mechanisms of intervertebral disc degeneration from an immune perspective

C Song, Y Zhou, K Cheng, F Liu, W Cai, D Zhou… - Biomedicine & …, 2023 - Elsevier
Intervertebral disc degeneration (IVDD) is a frequent and intractable chronic condition in
orthopedics that causes enormous discomfort in patients' lives and thoughts, as well as a …

Extracellular vesicles as an emerging treatment option for intervertebral disc degeneration: therapeutic potential, translational pathways, and regulatory considerations

TJ DiStefano, K Vaso, G Danias… - Advanced …, 2022 - Wiley Online Library
Emergent approaches in regenerative medicine look toward the use of extracellular vesicles
(EVs) as a next‐generation treatment strategy for intervertebral disc (IVD) degeneration …

[HTML][HTML] Progress in regulating inflammatory biomaterials for intervertebral disc regeneration

H **ang, W Zhao, K Jiang, J He, L Chen, W Cui, Y Li - Bioactive Materials, 2024 - Elsevier
Intervertebral disc degeneration (IVDD) is rising worldwide and leading to significant health
issues and financial strain for patients. Traditional treatments for IVDD can alleviate pain but …

Osteopontin deficiency promotes cartilaginous endplate degeneration by enhancing the NF-κB signaling to recruit macrophages and activate the NLRP3 …

Y Wang, W Zhang, Y Yang, J Qin, R Wang, S Wang… - Bone Research, 2024 - nature.com
Intervertebral disc degeneration (IDD) is a major cause of discogenic pain, and is attributed
to the dysfunction of nucleus pulposus, annulus fibrosus, and cartilaginous endplate (CEP) …

Magnoflorine alleviates “M1” polarized macrophage-induced intervertebral disc degeneration through repressing the HMGB1/Myd88/NF-κB pathway and NLRP3 …

F Zhao, Z Guo, F Hou, W Fan, B Wu… - Frontiers in …, 2021 - frontiersin.org
Intervertebral disc degeneration (IDD) is related to the deterioration of nucleus pulposus
(NP) cells due to hypertrophic differentiation and calcification. The imbalance of pro …

Honokiol alleviates the degeneration of intervertebral disc via suppressing the activation of TXNIP-NLRP3 inflammasome signal pathway

P Tang, JM Gu, ZA **e, Y Gu, ZW Jie, KM Huang… - Free Radical Biology …, 2018 - Elsevier
Intervertebral disc degeneration (IVDD) is a multifactorial disease and responsible for many
spine related disorders, causes disability in the workforce and heavy social costs all over the …

Repair strategies and bioactive functional materials for intervertebral disc

D Wu, G Li, X Zhou, W Zhang, H Liang… - Advanced Functional …, 2022 - Wiley Online Library
Intervertebral disc (IVD) degeneration is the leading cause of low back pain, which
represents a highly prevalent chronic aging‐associated disorder with a large socio …