Neddylation is one type of protein post‐translational modification by conjugating a ubiquitin‐
like protein neural precursor cell‐expressed developmentally downregulated protein 8 to …

Manipulation of host protein post-translational modifications (PTMs) is used by various
pathogens to interfere with host cell functions. Among these modifications, ubiquitin (UBI) …

Impaired wound healing associated with recurrent Staphylococcus aureus infection and
unresolved inflammation are hallmarks of nonhealing diabetic foot ulcers (DFUs). Perforin-2 …

Abstract Macrophage-expressed gene 1 (MPEG1/Perforin-2) is a perforin-like protein that
functions within the phagolysosome to damage engulfed microbes. MPEG1 is thought to …

Perforin-2 (P-2) is an antimicrobial protein with unique properties to kill intracellular bacteria.
Gamma delta (GD) T cells, as the major T cell population in epithelial tissues, play a central …

Perforin-2 (MPEG1) is a pore-forming, antibacterial protein with broad-spectrum activity.
Perforin-2 is expressed constitutively in phagocytes and inducibly in parenchymal, tissue …

Perforin-2 (MPEG1) is thought to enable the killing of invading microbes engulfed by
macrophages and other phagocytes, forming pores in their membranes. Loss of perforin-2 …

Macrophage-expressed gene 1 [MPEG1/Perforin-2 (PRF2)] is an ancient metazoan protein
belonging to the Membrane Attack Complex/Perforin (MACPF) branch of the …

Some bacterial pathogens modulate signaling pathways of eukaryotic cells in order to
subvert the host response for their own benefit, leading to successful colonization and …

Colorectal cancer (CRC) is a leading cause of cancer death worldwide, and its incidence is
correlated with infections, chronic inflammation, diet, and genetic factors. An emerging …