Repeated drug use can change dopamine (DA) function in ways that promote the
development and persistence of addiction, but in what direction? By one view, drug use …

The striatal dopamine system has long been studied in the context of reward learning,
motivation, and movement. Given the prominent role dopamine plays in a variety of adaptive …

The salience network (SN) and default mode network (DMN) play a crucial role in cognitive
function. The SN, anchored in the anterior insular cortex (AI), has been hypothesized to …

Animal whole-brain functional magnetic resonance imaging (fMRI) provides a non-invasive
window into brain activity. A collection of associated methods aims to replicate observations …

Background A wide range of neuropsychiatric disorders, from schizophrenia to drug
addiction, involve abnormalities in both the mesolimbic dopamine system and the cortical …

The neurotransmitter dopamine is required for the reinforcement of actions by rewarding
stimuli. Neuroscientists have tried to define the functions of dopamine in concise conceptual …

Decades of research suggest that the mesocortical dopamine system exerts powerful control
over mPFC physiology and function. Indeed, dopamine signaling in the medial prefrontal …

Abstracts Functional connectivity, which reflects the spatial and temporal organization of
intrinsic activity throughout the brain, is one of the most studied measures in human …

The molecular pathways underlying the induction and maintenance of long-term synaptic
plasticity have been extensively investigated revealing various mechanisms by which …

The development of current neuroleptics was largely aiming to decrease excessive
dopaminergic signaling in the striatum. However, the notion that abnormal dopamine …