Neuronal lipid metabolism: multiple pathways driving functional outcomes in health and disease
Lipids are a fundamental class of organic molecules implicated in a wide range of biological
processes related to their structural diversity, and based on this can be broadly classified …
processes related to their structural diversity, and based on this can be broadly classified …
Molecular and cellular mechanisms affected in ALS
L Le Gall, E Anakor, O Connolly… - Journal of personalized …, 2020 - mdpi.com
Amyotrophic lateral sclerosis (ALS) is a terminal late-onset condition characterized by the
loss of upper and lower motor neurons. Mutations in more than 30 genes are associated to …
loss of upper and lower motor neurons. Mutations in more than 30 genes are associated to …
Biomarkers in motor neuron disease: a state of the art review
NS Verber, SR Shepheard, M Sassani… - Frontiers in …, 2019 - frontiersin.org
Motor neuron disease can be viewed as an umbrella term describing a heterogeneous
group of conditions, all of which are relentlessly progressive and ultimately fatal. The …
group of conditions, all of which are relentlessly progressive and ultimately fatal. The …
Metabolomics of human brain aging and age-related neurodegenerative diseases
Neurons in the mature human central nervous system (CNS) perform a wide range of motor,
sensory, regulatory, behavioral, and cognitive functions. Such diverse functional output …
sensory, regulatory, behavioral, and cognitive functions. Such diverse functional output …
Neurodegenerative disorders of alzheimer, parkinsonism, amyotrophic lateral sclerosis and multiple sclerosis: an early diagnostic approach for precision treatment
Neurodegenerative diseases (NDs) are characterised by progressive dysfunction of
synapses, neurons, glial cells and their networks. Neurodegenerative diseases can be …
synapses, neurons, glial cells and their networks. Neurodegenerative diseases can be …
Untargeted metabolomics yields insight into ALS disease mechanisms
Objective To identify dysregulated metabolic pathways in amyotrophic lateral sclerosis (ALS)
versus control participants through untargeted metabolomics. Methods Untargeted …
versus control participants through untargeted metabolomics. Methods Untargeted …
[PDF][PDF] Power of metabolomics in diagnosis and biomarker discovery of hepatocellular carcinoma
X Wang, A Zhang, H Sun - Hepatology, 2013 - Wiley Online Library
Hepatocellular carcinoma (HCC) is the commonest primary hepatic malignancy and the third
most common cause of cancer‐related death worldwide. Incidence remains highest in the …
most common cause of cancer‐related death worldwide. Incidence remains highest in the …
Metabolic biomarkers and neurodegeneration: a pathway enrichment analysis of Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis
Neurodegenerative diseases such as Alzheimer's disease (AD), Parkinson's disease (PD),
and amyotrophic lateral sclerosis (ALS) lack robust diagnostics and prognostic biomarkers …
and amyotrophic lateral sclerosis (ALS) lack robust diagnostics and prognostic biomarkers …
The autophagic tumor stroma model of cancer: Role of oxidative stress and ketone production in fueling tumor cell metabolism
A loss of stromal Cav-1 in the tumor fibroblast compartment is associated with early tumor
recurrence, lymph-node metastasis, and tamoxifen-resistance, resulting in poor clincical …
recurrence, lymph-node metastasis, and tamoxifen-resistance, resulting in poor clincical …
The glutamate hypothesis in ALS: pathophysiology and drug development
H Blasco, S Mavel, P Corcia… - Current medicinal …, 2014 - ingentaconnect.com
Amyotrophic lateral sclerosis (ALS) is an age-related neurodegenerative disorder that is
believed to have complex genetic and environmental influences in the pathogenesis, but …
believed to have complex genetic and environmental influences in the pathogenesis, but …