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Current approaches to the management of brain metastases
Brain metastases are a very common manifestation of cancer that have historically been
approached as a single disease entity given the uniform association with poor clinical …
approached as a single disease entity given the uniform association with poor clinical …
Brain metastases: A Society for Neuro-Oncology (SNO) consensus review on current management and future directions
Brain metastases occur commonly in patients with advanced solid malignancies. Yet, less is
known about brain metastases than cancer-related entities of similar incidence. Advances in …
known about brain metastases than cancer-related entities of similar incidence. Advances in …
Hippocampal avoidance during whole-brain radiotherapy plus memantine for patients with brain metastases: phase III trial NRG oncology CC001
PURPOSE Radiation dose to the neuroregenerative zone of the hippocampus has been
found to be associated with cognitive toxicity. Hippocampal avoidance (HA) using intensity …
found to be associated with cognitive toxicity. Hippocampal avoidance (HA) using intensity …
Postoperative stereotactic radiosurgery compared with whole brain radiotherapy for resected metastatic brain disease (NCCTG N107C/CEC· 3): a multicentre …
Background Whole brain radiotherapy (WBRT) is the standard of care to improve intracranial
control following resection of brain metastasis. However, stereotactic radiosurgery (SRS) to …
control following resection of brain metastasis. However, stereotactic radiosurgery (SRS) to …
Effect of radiosurgery alone vs radiosurgery with whole brain radiation therapy on cognitive function in patients with 1 to 3 brain metastases: a randomized clinical trial
Importance Whole brain radiotherapy (WBRT) significantly improves tumor control in the
brain after stereotactic radiosurgery (SRS), yet because of its association with cognitive …
brain after stereotactic radiosurgery (SRS), yet because of its association with cognitive …
Enhanced cisplatin chemotherapy by iron oxide nanocarrier-mediated generation of highly toxic reactive oxygen species
Reactive oxygen species (ROS) plays a key role in therapeutic effects as well as side effects
of platinum drugs. Cisplatin mediates activation of nicotinamide adenine dinucleotide …
of platinum drugs. Cisplatin mediates activation of nicotinamide adenine dinucleotide …
Depatuxizumab mafodotin in EGFR-amplified newly diagnosed glioblastoma: a phase III randomized clinical trial
Background Approximately 50% of newly diagnosed glioblastomas (GBMs) harbor
epidermal growth factor receptor gene amplification (EGFR-amp). Preclinical and early …
epidermal growth factor receptor gene amplification (EGFR-amp). Preclinical and early …
Memantine for the prevention of cognitive dysfunction in patients receiving whole-brain radiotherapy: a randomized, double-blind, placebo-controlled trial
Background To determine the protective effects of memantine on cognitive function in
patients receiving whole-brain radiotherapy (WBRT). Methods Adult patients with brain …
patients receiving whole-brain radiotherapy (WBRT). Methods Adult patients with brain …
Cognitive impairment associated with cancer: a brief review
JC Pendergrass, SD Targum… - Innovations in clinical …, 2018 - pmc.ncbi.nlm.nih.gov
This brief review explores the areas of cognitive impairment that have been observed in
cancer patients and survivors, the cognitive assessment tools used, and the management of …
cancer patients and survivors, the cognitive assessment tools used, and the management of …
Diagnosis-specific prognostic factors, indexes, and treatment outcomes for patients with newly diagnosed brain metastases: a multi-institutional analysis of 4,259 …
PURPOSE: Controversy endures regarding the optimal treatment of patients with brain
metastases (BMs). Debate persists, despite many randomized trials, perhaps because BM …
metastases (BMs). Debate persists, despite many randomized trials, perhaps because BM …