The surprising discovery that the diatomic gas nitric oxide (NO) is generated by mammalian
cells and serves to regulate a multitude of physiological processes has continued to …

Cellular mechanotransduction, a critical regulator of numerous biological processes, is the
conversion from mechanical signals to biochemical signals regarding cell activities and …

This review aims to survey the current state of mechanotransduction in vascular smooth
muscle cells (VSMCs) and endothelial cells (ECs), including their sensing of mechanical …

PIEZO channels respond to piconewton-scale forces to mediate critical physiological and
pathophysiological processes,,,–. Detergent-solubilized PIEZO channels form bowl-shaped …

Mechanical force is an essential physical element that contributes to the formation and
function of life. The discovery of the evolutionarily conserved PIEZO family, including PIEZO1 …

Direct recognition of invading pathogens by innate immune cells is a critical driver of the
inflammatory response. However, cells of the innate immune system can also sense their …

Activation of stretch-sensitive baroreceptor neurons exerts acute control over heart rate and
blood pressure. Although this homeostatic baroreflex has been described for more than 80 …

Mechanical load of the skeleton system is essential for the development, growth, and
maintenance of bone. However, the molecular mechanism by which mechanical stimuli are …

Cellular mechanotransduction, the process of translating mechanical forces into biological
signals, is crucial for a wide range of physiological processes. A role for ion channels in …

Mechanotransduction is a fundamental ability that allows living organisms to receive and
respond to physical signals from both the external and internal environments. The …