Cancer management is major concern of health organizations and viral cancers account for
approximately 15.4% of all known human cancers. Due to large number of patients, efficient …

The rising global burden of cancer has driven considerable efforts into the research and
development of effective anti-cancer agents. Fortunately, with impressive advances in …

With the emergence of high-throughput technologies, computational screening based on
gene expression profiles has become one of the most effective methods for drug discovery …

Tumor-initiating cells (TICs) possess the ability to evade anti-tumor immunity, potentially
explaining many failures of cancer immunotherapy. Here, we identify CD49f as a prominent …

Background Using interpretable machine learning, we sought to define the immune
microenvironment subtypes and distinctive genes in AD. Methods ssGSEA, LASSO …

The immune cells play an increasingly vital role in influencing the proliferation, progression,
and metastasis of lung adenocarcinoma (LUAD) cells. However, the potential of immune …

Immune evasion and metabolism reprogramming have been regarded as two vital hallmarks
of the mechanism of carcinogenesis. Thus, targeting the immune microenvironment and the …

Purpose Recent studies have increasingly linked Ephrin receptor B2 (EPHB2) to cancer
progression. However, comprehensive investigations into the immunological roles and …

Background Numerous studies have used multi-region sampling approaches to characterize
intra-tumor heterogeneity (ITH) in hepatocellular carcinoma (HCC). However, conventional …

Abstract Background Approximately 20–50% of patients presenting with localized colorectal
cancer progress to stage IV metastatic disease (mCRC) following initial treatment and this is …