Autoimmune liver diseases are chronic inflammatory hepatobiliary disorders that when
classically defined encompass three distinctive clinical presentations; primary biliary …

Non-alcoholic fatty liver disease (NAFLD) is the leading cause of liver diseases in high-
income countries and the burden of NAFLD is increasing at an alarming rate. The risk of …

Abbreviations: AASLD, American Association for the Study of Liver Diseases; AIH,
autoimmune hepatitis; ALP, alkaline phosphatase; ASIR, age standardized incidence rate; …

Current catalogs of regulatory sequences in the human genome are still incomplete and lack
cell type resolution. To profile the activity of gene regulatory elements in diverse cell types …

Increasing rates of autoimmune and inflammatory disease present a burgeoning threat to
human health. This is compounded by the limited efficacy of available treatments and high …

Genetic risk variants that have been identified in genome-wide association studies of
complex diseases are primarily non-coding. Translating these risk variants into mechanistic …

Objective: The authors investigated the pathways (genetic, environmental, lifestyle, medical)
leading to inflammation in major depressive disorder using C-reactive protein (CRP) …

Many chronic diseases are marked by fibrosis, which is defined by an abundance of
activated fibroblasts and excessive deposition of extracellular matrix, resulting in loss of …

Autoimmune and inflammatory diseases are polygenic disorders of the immune system.
Many genomic loci harbor risk alleles for several diseases, but the limited resolution of …

Interleukin-2 (IL-2), the first cytokine that was molecularly cloned, was shown to be a T cell
growth factor essential for the proliferation of T cells and the generation of effector and …