The cerebral vascular system services the constant demand for energy during neuronal
activity in the brain. Attempts to delineate the logic of neurovascular coupling have been …

Functional magnetic resonance imaging (fMRI) has allowed the noninvasive study of task-
based and resting-state brain dynamics in humans by inferring neural activity from blood …

The ε4 allele of the apolipoprotein E (APOE) gene, a genetic risk factor for Alzheimer's
disease, is abundantly expressed in both the brain and periphery. Here, we present …

The majority of the brain's vasculature is composed of intricate capillary networks lined by
capillary pericytes. However, it remains unclear whether capillary pericytes influence blood …

The hippocampus is essential for spatial and episodic memory but is damaged early in
Alzheimer's disease and is very sensitive to hypoxia. Understanding how it regulates its …

Microglia are the main immune cells of the brain and contribute to common brain diseases.
However, it is unclear how microglia influence neuronal activity and survival in the injured …

We present a method to form an optical window in the mouse skull that spans millimeters
and is stable for months without causing brain inflammation. This enabled us to repeatedly …

Characterizing blood flow dynamics in vivo is critical to understanding the function of the
vascular network under physiological and pathological conditions. Existing methods for …

Spontaneous fluctuations in hemodynamic signals in the absence of a task or overt
stimulation are used to infer neural activity. We tested this coupling by simultaneously …

Aging is frequently associated with compromised cerebrovasculature and pericytes.
However, we do not know how normal aging differentially impacts vascular structure and …