Within the tumor microenvironment, IL-6 signaling is generally considered a malevolent
player, assuming a dark visage that promotes tumor progression. Chronic IL-6 signaling is …

This review examines the effects of thermal stress on gene expression, with special
emphasis on changes in the expression of genes other than heat shock proteins (HSPs) …

Fever, a nonspecific acute-phase response, has been associated with improved survival
and shortened disease duration in infections, but the mechanisms of these beneficial …

Sepsis is a highly lethal clinical syndrome characterized by a systemic inflammatory
response to infection. Fever, a non-specific acute-phase response, has been associated …

Recovery from systemic or local bacterial infections can be lengthy and costly, with the
clinical challenges being further complicated when bacteria acquire resistance to current …

The heat shock response is an ancient and highly conserved process that is essential for
surviving environmental stresses, including extremes of temperature. Fever is a more …

The heat shock response is a highly conserved primitive response that is essential for
survival against a wide range of stresses, including extremes of temperature. Fever is a …

Endotoxic fever is regulated by endogenous factors that provide pro-and anti-pyretic signals
at different points along the febrigenic pathway, from the periphery to the brain. Current …

Sensory nerves innervating the lung and airways play an important role in regulating various
cardiopulmonary functions and maintaining homeostasis under both healthy and disease …

Tumor necrosis factor-α (TNFα) is a pivotal early mediator of host defenses that is essential
for survival in infections. We previously reported that exposing macrophages to febrile range …