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Biological soft matter: intrinsically disordered proteins in liquid–liquid phase separation and biomolecular condensates
The facts that many proteins with crucial biological functions do not have unique structures
and that many biological processes are compartmentalized into the liquid-like biomolecular …
and that many biological processes are compartmentalized into the liquid-like biomolecular …
[HTML][HTML] Protein structure-based in-silico approaches to drug discovery: Guide to COVID-19 therapeutics
With more than 5 million fatalities and close to 300 million reported cases, COVID-19 is the
first documented pandemic due to a coronavirus that continues to be a major health …
first documented pandemic due to a coronavirus that continues to be a major health …
COV2Var, a function annotation database of SARS-CoV-2 genetic variation
The COVID-19 pandemic, caused by the coronavirus SARS-CoV-2, has resulted in the loss
of millions of lives and severe global economic consequences. Every time SARS-CoV-2 …
of millions of lives and severe global economic consequences. Every time SARS-CoV-2 …
Chandipura virus forms cytoplasmic inclusion bodies through phase separation and proviral association of cellular protein kinase R and stress granule protein TIA-1
Negative-strand RNA viruses form cytoplasmic inclusion bodies (IBs) representing virus
replication foci through phase separation or biomolecular condensation of viral and cellular …
replication foci through phase separation or biomolecular condensation of viral and cellular …
An integrated understanding of the evolutionary and structural features of the SARS-CoV-2 spike receptor binding domain (RBD)
Conventional drug development strategies typically use pocket in protein structures as drug-
target sites. They overlook the plausible effects of protein evolvability and resistant mutations …
target sites. They overlook the plausible effects of protein evolvability and resistant mutations …
Understanding the SARS-CoV-2–human liver interactome using a comprehensive analysis of the individual virus–host interactions
Many metabolic processes at the molecular level support both viral attack strategies and
human defenses during COVID-19. This knowledge is of vital importance in the design of …
human defenses during COVID-19. This knowledge is of vital importance in the design of …
Mesophiles vs. Thermophiles: Untangling the Hot Mess of Intrinsically Disordered Proteins and Growth Temperature of Bacteria
The dynamic structures and varying functions of intrinsically disordered proteins (IDPs) have
made them fascinating subjects in molecular biology. Investigating IDP abundance in …
made them fascinating subjects in molecular biology. Investigating IDP abundance in …
SARS-CoV-2 NSP2 as a Potential Delivery Vehicle for Proteins
N Zheng, S Liu, J Chen, Y Xu, W Cao, J Lin… - Molecular …, 2024 - ACS Publications
The development of biomolecule delivery systems is essential for the treatment of various
diseases such as cancer, immunological diseases, and metabolic disorders. For the first …
diseases such as cancer, immunological diseases, and metabolic disorders. For the first …
Investigation of protein-protein interactions and hotspot region on the NSP7-NSP8 binding site in NSP12 of SARS-CoV-2
Background: The RNA-dependent RNA polymerase (RdRp) complex, essential in viral
transcription and replication, is a key target for antiviral therapeutics. The core unit of RdRp …
transcription and replication, is a key target for antiviral therapeutics. The core unit of RdRp …
[HTML][HTML] Hepatitis c virus infection and intrinsic disorder in the signaling pathways induced by toll-like receptors
Simple Summary Human hepatitis C virus causes contagious liver disease hepatitis C,
which is broadly spread around the globe. Infection with this virus causes an inflammation of …
which is broadly spread around the globe. Infection with this virus causes an inflammation of …