The human body at cellular resolution: the NIH Human Biomolecular Atlas Program
Caltech-UW TMC Cai Long lcai@ caltech. edu 21 b … - Nature, 2019 - nature.com
Transformative technologies are enabling the construction of three-dimensional maps of
tissues with unprecedented spatial and molecular resolution. Over the next seven years, the …
tissues with unprecedented spatial and molecular resolution. Over the next seven years, the …
Comparing DESI-MSI and MALDI-MSI mediated spatial metabolomics and their applications in cancer studies
Metabolic heterogeneity of cancer contributes significantly to its poor treatment outcomes
and prognosis. As a result, studies continue to focus on identifying new biomarkers and …
and prognosis. As a result, studies continue to focus on identifying new biomarkers and …
High spatial resolution imaging of biological tissues using nanospray desorption electrospray ionization mass spectrometry
Mass spectrometry imaging (MSI) enables label-free spatial map** of hundreds of
biomolecules in tissue sections. This capability provides valuable information on tissue …
biomolecules in tissue sections. This capability provides valuable information on tissue …
Highly multiplexed, label-free proteoform imaging of tissues by individual ion mass spectrometry
Imaging of proteoforms in human tissues is hindered by low molecular specificity and limited
proteome coverage. Here, we introduce proteoform imaging mass spectrometry (PiMS) …
proteome coverage. Here, we introduce proteoform imaging mass spectrometry (PiMS) …
SEAM is a spatial single nuclear metabolomics method for dissecting tissue microenvironment
Z Yuan, Q Zhou, L Cai, L Pan, W Sun, S Qumu, S Yu… - Nature …, 2021 - nature.com
Spatial metabolomics can reveal intercellular heterogeneity and tissue organization. Here
we report on the spatial single nuclear metabolomics (SEAM) method, a flexible platform …
we report on the spatial single nuclear metabolomics (SEAM) method, a flexible platform …
Matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI MSI) for in situ analysis of endogenous small molecules in biological samples
H Liu, Y Pan, C ** for
a broad range of molecular classes, facilitating in situ biological discovery. Yet, challenges …
a broad range of molecular classes, facilitating in situ biological discovery. Yet, challenges …
Desorption electrospray ionization mass spectrometry imaging in discovery and development of novel therapies
Desorption electrospray ionization mass spectrometry imaging (DESI‐MSI) is one of the
least specimen destructive ambient ionization mass spectrometry tissue imaging methods. It …
least specimen destructive ambient ionization mass spectrometry tissue imaging methods. It …