Red blood cell abnormalities and the pathogenesis of anemia in end‐stage renal disease

HT Georgatzakou, MH Antonelou… - PROTEOMICS …, 2016 - Wiley Online Library
Anemia is the most common hematologic complication in end‐stage renal disease (ESRD).
It is ascribed to decreased erythropoietin production, shortened red blood cell (RBC) …

'Gardos Channelopathy': a variant of hereditary Stomatocytosis with complex molecular regulation

E Fermo, A Bogdanova, P Petkova-Kirova… - Scientific reports, 2017 - nature.com
The Gardos channel is a Ca2+ sensitive, K+ selective channel present in several tissues
including RBCs, where it is involved in cell volume regulation. Recently, mutations at two …

Red cell properties after different modes of blood transportation

A Makhro, R Huisjes, LP Verhagen… - Frontiers in …, 2016 - frontiersin.org
Transportation of blood samples is unavoidable for assessment of specific parameters in
blood of patients with rare anemias, blood do** testing, or for research purposes. Despite …

Is increased intracellular calcium in red blood cells a common component in the molecular mechanism causing anemia?

L Hertz, R Huisjes, E Llaudet-Planas… - Frontiers in …, 2017 - frontiersin.org
For many hereditary disorders, although the underlying genetic mutation may be known, the
molecular mechanism leading to hemolytic anemia is still unclear and needs further …

Intracellular Ca2+ Concentration and Phosphatidylserine Exposure in Healthy Human Erythrocytes in Dependence on in vivo Cell Age

I Bernhardt, DB Nguyen, MC Wesseling… - Frontiers in …, 2020 - frontiersin.org
After about 120 days of circulation in the blood stream, erythrocytes are cleared by
macrophages in the spleen and the liver. The “eat me” signal of this event is thought to be …

Regulation of red cell life-span, erythropoiesis, senescence, and clearance

L Kaestner, A Bogdanova - Frontiers in physiology, 2014 - frontiersin.org
The number of red blood cells (RBCs) and their properties are optimized by nature for most
efficient oxygen delivery from the lungs to hypoxic periphery. Changes in metabolic …

Is there a role of C‐reactive protein in red blood cell aggregation?

D Flormann, E Kuder, P Lipp, C Wagner… - … journal of laboratory …, 2015 - Wiley Online Library
Introduction Numerous clinical studies related the plasma level of C‐reactive protein (CRP)
to the erythrocyte sedimentation rate (ESR) independent of the kind of disease. The …

Does erythropoietin regulate TRPC channels in red blood cells?

J Danielczok, L Hertz, S Ruppenthal, E Kaiser… - Cellular Physiology and …, 2017 - karger.com
Background: Cation channels play an essential role in red blood cells (RBCs) ion
homeostasis. One set of ion channels are the transient receptor potential channels of …

The uremic solute 3-carboxy-4-methyl-5-propyl-2-furanpropionate (CMPF) may enhance eryptosis and increase erythrocyte osmotic fragility through potential …

BAK Van Spitzenbergen, GB Andrade… - Nephrology Dialysis …, 2024 - academic.oup.com
Background and hypothesis In patients with advanced chronic kidney disease (CKD), the
lifespan of red blood cells (RBC) is often shortened, a condition attributed to the “uremic …

Epoetin beta pegol for treatment of anemia ameliorates deterioration of erythrocyte quality associated with chronic kidney disease

K Aizawa, R Kawasaki, Y Tashiro, Y Shimonaka… - BMC nephrology, 2018 - Springer
Background Epoetin beta pegol (continuous erythropoietin receptor activator; CERA) is
currently widely used for the treatment of anemia associated with chronic kidney disease …