In this Review, we describe the singular success of attractor neural network models in
describing how the brain maintains persistent activity states for working memory, corrects …

The zebrafish visual system has become a paradigmatic preparation for behavioral and
systems neuroscience. Around 40 types of retinal ganglion cells (RGCs) serve as matched …

We assembled a semi-automated reconstruction of L2/3 mouse primary visual cortex from∼
250× 140× 90 μm 3 of electron microscopic images, including pyramidal and non-pyramidal …

Dense reconstruction of synaptic connectivity requires high-resolution electron microscopy
images of entire brains and tools to efficiently trace neuronal wires across the volume. To …

To understand the brain we must relate neurons' functional responses to the circuit
architecture that shapes them. Here, we present a large functional connectomics dataset …

When 3D electron microscopy and calcium imaging are used to investigate the structure and
function of neural circuits, the resulting datasets pose new challenges of visualization and …

Neurological diseases are on the rise worldwide, leading to increased healthcare costs and
diminished quality of life in patients. In recent years, Big Data has started to transform the …

Electron microscopy (EM) is widely used for studying cellular structure and network
connectivity in the brain. We have built a parallel imaging pipeline using transmission …

Simultaneous recordings of large populations of neurons in behaving animals allow detailed
observation of high-dimensional, complex brain activity. However, experimental approaches …

Visual stimuli can evoke complex behavioral responses, but the underlying streams of
neural activity in mammalian brains are difficult to follow because of their size. Here, I review …