Numerous studies have demonstrated that endothelial cells are capable of undergoing
endothelial to mesenchymal transition (EndMT), a newly recognized type of cellular …

Fibrotic diseases are characterized by net accumulation of extracellular matrix proteins in
affected organs leading to their dysfunction and ultimate failure. Myofibroblasts have been …

Endothelial to mesenchymal transition (EndMT) is a complex biological process that gives
rise to cells with multipotent potential. EndMT is essential for the formation of the …

Endothelial cells that line the inner walls of blood vessels are in direct contact with blood
and display remarkable heterogeneity in their response to exogenous stimuli. These ECs …

Fibrotic diseases encompass a wide spectrum of clinical entities including systemic fibrotic
diseases such as systemic sclerosis, sclerodermatous graft versus host disease …

The tumor microenvironment (TME) consists of various components including cancer cells,
tumor vessels, cancer‐associated fibroblasts (CAFs), and inflammatory cells. These …

Recent advances in our understanding of the molecular pathways that control the link of
inflammation with organ fibrosis and autoimmune diseases point to the epithelial to …

During the last decade, the endothelial-to-mesenchymal transition (EndMT) process has
attracted considerable attention due to associations with the onset of certain diseases, such …

Cardiac remodeling, which is characterized by mechanical and electrical remodeling, is a
significant pathophysiological process involved in almost all forms of heart diseases …

Transforming growth factor (TGF)-β regulates a wide variety of cellular responses, including
cell growth arrest, apoptosis, cell differentiation, motility, invasion, extracellular matrix …