The urokinase‐type plasminogen activator (u‐PA) system consists of the serine proteinases
plasmin and u‐PA; the serpin inhibitors α2‐anti‐plasmin, PAI‐1 and PAI‐2; and the u‐PA …

The invasive nature of brain-tumour cells makes an important contribution to the
ineffectiveness of current treatment modalities, as the remaining tumour cells inevitably …

The poor survival of patients with human malignant gliomas relates partly to the inability to
deliver therapeutic agents to the tumor. Because it has been suggested that circulating bone …

Necrosis and vascular proliferation are the pathologic features that distinguish the most
malignant infiltrative astrocytoma, glioblastoma (GBM), from those of lower grades. In GBM …

The invasion of neoplastic cells into healthy brain tissue is a pathologic hallmark of gliomas
and contributes to the failure of current therapeutic modalities (surgery, radiation and …

Abstract INVADING GLIOMA CELLS seem to follow distinct anatomic structures within the
central nervous system. Tumor cell dissemination may occur along structures, such as the …

Glioblastoma is the most common primary brain tumor and has a dismal prognosis. The
development of central necrosis represents a tip** point in the evolution of these tumors …

MicroRNAs (miRNAs) are effective post‐transcriptional regulators of gene expression and
are important in many biological processes. Although the oncogenic and tumor suppressive …

MicroRNAs are small endogenous noncoding RNAs, which modulate target gene
expression by binding with target mRNA sequences in the 3′ untranslated region (UTR) …

The survival of cancer patients suffering from glioblastoma multiforme is limited to just a few
months even after treatment with the most advanced techniques. The indefinable borders of …