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Cell and circuit complexity of the external globus pallidus
The external globus pallidus (GPe) of the basal ganglia has been underappreciated owing
to poor understanding of its cells and circuits. It was assumed that the GPe consisted of a …
to poor understanding of its cells and circuits. It was assumed that the GPe consisted of a …
Updating the striatal–pallidal wiring diagram
The striatal and pallidal complexes are basal ganglia structures that orchestrate learning
and execution of flexible behavior. Models of how the basal ganglia subserve these …
and execution of flexible behavior. Models of how the basal ganglia subserve these …
Simple Behavioral Analysis (SimBA) as a platform for explainable machine learning in behavioral neuroscience
The study of complex behaviors is often challenging when using manual annotation due to
the absence of quantifiable behavioral definitions and the subjective nature of behavioral …
the absence of quantifiable behavioral definitions and the subjective nature of behavioral …
Population-specific neuromodulation prolongs therapeutic benefits of deep brain stimulation
Symptoms of neurological diseases emerge through the dysfunction of neural circuits whose
diffuse and intertwined architectures pose serious challenges for delivering therapies. Deep …
diffuse and intertwined architectures pose serious challenges for delivering therapies. Deep …
The indirect pathway of the basal ganglia promotes transient punishment but not motor suppression
Optogenetic stimulation of Adora2a receptor-expressing spiny projection neurons (A2A-
SPNs) in the striatum drives locomotor suppression and transient punishment, results …
SPNs) in the striatum drives locomotor suppression and transient punishment, results …
Learning critically drives parkinsonian motor deficits through imbalanced striatal pathway recruitment
Dopamine (DA) loss in Parkinson's disease (PD) causes debilitating motor deficits.
However, dopamine is also widely linked to reward prediction and learning, and the …
However, dopamine is also widely linked to reward prediction and learning, and the …
Ventral pallidal regulation of motivated behaviors and reinforcement
The interconnected nuclei of the ventral basal ganglia have long been identified as key
regulators of motivated behavior, and dysfunction of this circuit is strongly implicated in …
regulators of motivated behavior, and dysfunction of this circuit is strongly implicated in …
Emotion in action: When emotions meet motor circuits
The brain is a remarkably complex organ responsible for a wide range of functions,
including the modulation of emotional states and movement. Neuronal circuits are believed …
including the modulation of emotional states and movement. Neuronal circuits are believed …
Vocal learning–associated convergent evolution in mammalian proteins and regulatory elements
Vocal production learning (“vocal learning”) is a convergently evolved trait in vertebrates. To
identify brain genomic elements associated with mammalian vocal learning, we integrated …
identify brain genomic elements associated with mammalian vocal learning, we integrated …
A non-canonical striatopallidal Go pathway that supports motor control
In the classical model of the basal ganglia, direct pathway striatal projection neurons
(dSPNs) send projections to the substantia nigra (SNr) and entopeduncular nucleus to …
(dSPNs) send projections to the substantia nigra (SNr) and entopeduncular nucleus to …