Protein–protein interactions (PPIs) are of pivotal importance in the regulation of biological
systems and are consequently implicated in the development of disease states. Recent work …

Homologous recombination (HR) is a major pathway for the repair of DNA double-strand
breaks in mammalian cells, the defining step of which is homologous strand exchange …

The tumour suppressor complex BRCA1–BARD1 functions in the repair of DNA double-
stranded breaks by homologous recombination. During this process, BRCA1–BARD1 …

The proteins encoded by the two major breast cancer susceptibility genes, BRCA1 and
BRCA2, work in a common pathway of genome protection. However, the two proteins work …

Background Germline mutations in the BRCA1 or BRCA2 (BRCA) genes predispose to
hereditary breast and ovarian cancer and, mostly in the case of BRCA2, are also prevalent …

In the last two decades, an increasing amount of studies have investigated the use of
components based on carbon-(nano) materials in the engineering of neural interfaces, to …

Mitotic homologous recombination promotes genome stability through the precise repair of
DNA double-strand breaks and other lesions that are encountered during normal cellular …

Maintenance of genome stability is essential for avoiding the passage to neoplasia. The
DNA-damage response—a cornerstone of genome stability—occurs by a swift transduction …

Homologous recombination (HR) serves to eliminate deleterious lesions, such as double-
stranded breaks and interstrand crosslinks, from chromosomes. HR is also critical for the …

Homologous recombination (HR) is critical both for repairing DNA lesions in mitosis and for
chromosomal pairing and exchange during meiosis. However, some forms of HR can also …