Hepatocellular carcinoma (HCC) accounts for about 90% of all primary liver cancers and is
the second leading cause of cancer-related deaths worldwide. The hypervascular nature of …

New blood vessels formation from the existing vasculature is called angiogenesis. It is an
essential physiological process for the growth of cells, tissue repair, wound healing, and …

Combination approaches are needed to strengthen and extend the clinical response to
KRASG12C inhibitors (KRASG12Ci). Here, we assessed the antitumor responses of …

Obesity originates from an imbalance between caloric intake and energy expenditure that
promotes adipose tissue expansion, which is necessary to buffer nutrient excess. Patients …

Angiogenesis, or the formation of new capillary blood vessels, occurs primarily during
human development and reproduction; however, aberrant regulation of angiogenesis is also …

Background Morbidity and mortality in pulmonary arterial hypertension (PAH) remain high.
Activation of platelet-derived growth factor receptor, colony stimulating factor 1 receptor, and …

As a progressive chronic disease, age-related macular degeneration (AMD) is the leading
cause of irreversible vision impairment worldwide. Experimental and clinical evidence has …

Abstract Activating B-RAF (V600E)(also known as BRAF) kinase mutations occur in∼ 7% of
human malignancies and∼ 60% of melanomas. Early clinical experience with a novel class …

Regenerative endodontic procedures for immature permanent teeth with apical periodontitis
confer biological advantages such as tooth homeostasis, enhanced immune defense …

Background Signalling through platelet-derived growth factor receptor (PDGFR), colony-
stimulating factor 1 receptor (CSF1R) and mast/stem cell growth factor receptor kit (c-KIT) …