Intrinsically disordered proteins in cellular signalling and regulation
PE Wright, HJ Dyson - Nature reviews Molecular cell biology, 2015 - nature.com
Intrinsically disordered proteins (IDPs) are important components of the cellular signalling
machinery, allowing the same polypeptide to undertake different interactions with different …
machinery, allowing the same polypeptide to undertake different interactions with different …
Targeting the p53–MDM2 interaction to treat cancer
The tumour suppressor p53 is a transcription factor with powerful antitumour activity that is
controlled by its negative regulator MDM2 (mouse double minute 2, also termed HDM2 in …
controlled by its negative regulator MDM2 (mouse double minute 2, also termed HDM2 in …
Graded enhancement of p53 binding to CREB-binding protein (CBP) by multisite phosphorylation
The transcriptional activity of p53 is regulated by a cascade of posttranslational
modifications. Although acetylation of p53 by CREB-binding protein (CBP)/p300 is known to …
modifications. Although acetylation of p53 by CREB-binding protein (CBP)/p300 is known to …
Terphenyl-based helical mimetics that disrupt the p53/HDM2 interaction
Abstract (Chemical Equation Presented) HDM2 regulates p53 by binding to its
transactivation domain and promoting its ubiquitin-dependent degradation. Crystallographic …
transactivation domain and promoting its ubiquitin-dependent degradation. Crystallographic …
New insights into cancer: MDM2 binds to the citrullinating enzyme PADI4
PADI4 is one of the human isoforms of a family of enzymes implicated in the conversion of
arginine to citrulline. MDM2 is an E3 ubiquitin ligase which is crucial for down‐regulation of …
arginine to citrulline. MDM2 is an E3 ubiquitin ligase which is crucial for down‐regulation of …
[HTML][HTML] Dual-site regulation of MDM2 E3-ubiquitin ligase activity
M Wallace, E Worrall, S Pettersson, TR Hupp, KL Ball - Molecular cell, 2006 - cell.com
The control of p53 ubiquitination by MDM2 provides a model system to define how an E3-
ligase functions on a conformationally flexible substrate. The mechanism of MDM2-mediated …
ligase functions on a conformationally flexible substrate. The mechanism of MDM2-mediated …
Structural details on mdm2-p53 interaction
SW Chi, SH Lee, DH Kim, MJ Ahn, JS Kim… - Journal of Biological …, 2005 - ASBMB
Mdm2 is a cellular antagonist of p53 that keeps a balanced cellular level of p53. The two
proteins are linked by a negative regulatory feedback loop and physically bind to each other …
proteins are linked by a negative regulatory feedback loop and physically bind to each other …
Structure of free MDM2 N-terminal domain reveals conformational adjustments that accompany p53-binding
S Uhrinova, D Uhrin, H Powers, K Watt… - Journal of molecular …, 2005 - Elsevier
Critical to the inhibitory action of the oncogene product, MDM2, on the tumour suppressor,
p53, is association of the N-terminal domain of MDM2 (MDM2N) with the transactivation …
p53, is association of the N-terminal domain of MDM2 (MDM2N) with the transactivation …
Probing the structural requirements of peptoids that inhibit hDM2− p53 interactions
T Hara, SR Durell, MC Myers… - Journal of the American …, 2006 - ACS Publications
Many cellular processes are controlled by protein− protein interactions, and selective
inhibition of these interactions could lead to the development of new therapies for several …
inhibition of these interactions could lead to the development of new therapies for several …
Structure–activity studies in a family of β‐Hairpin protein epitope mimetic inhibitors of the p53–HDM2 protein–protein interaction
Inhibitors of the interaction between the p53 tumor‐suppressor protein and its natural human
inhibitor HDM2 are attractive as potential anticancer agents. In earlier work we explored …
inhibitor HDM2 are attractive as potential anticancer agents. In earlier work we explored …