Abstract Background/Objective To analyze changes in recurrent/refractory osteosarcoma
phase II trials over time to inform future trials in this population with poor prognosis. Methods …

Osteosarcoma (OS), the most common malignant tumor in the musculoskeletal system,
mainly occurs in adolescents. OS results in high mortality and disability rates due to a fatal …

Osteosarcoma (OS) is the most common primary bone cancer in children and young adults,
patient survival rates have not improved in recent decades. To further understand the …

Improving the prognosis and cure rate of HGOSs (high-grade osteosarcomas) is an absolute
need. Immune-based treatment approaches have been increasingly taken into …

Simple Summary Jaw osteosarcoma (JO) differs from its long-bones counterpart in many
ways. The pathophysiology of this disease is still unknown, but the tumor microenvironment …

Cancer treatment remains a significant challenge due to issues such as acquired resistance
to conventional therapies and the occurrence of adverse treatment-related toxicities. In …

CD47 is expressed on cell surfaces and acts as a “don't eat me” signal by interacting with
signal-regulatory protein-α on the macrophage surface. Some cancer cells express CD47 …

Osteosarcoma, a primary malignant bone tumor commonly found in adolescents, is highly
aggressive, with a high rate of disability and mortality. It has a profound negative impact on …

ABSTRACT Objective Tumour‐associated macrophages (TAMs) are crucial in the
progression and treatment response of oral squamous cell carcinoma (OSCC). TAMs …

Abstract Acute Myeloid Leukemia (AML) is a hematological malignancy of the myeloid
lineage of immune cells in the blood and bone marrow. It is characterized by low five-year …