Colorectal cancer (CRC) is the second most common cancer in women and the third most
common in men. Adenocarcinoma accounts for 90% of CRC cases. There has been …

The Myc family of oncogenes is deregulated in many types of cancer, and their over-
expression is often correlated with poor prognosis. The Myc family members are …

The SALL4 transcription factor is associated with embryonic cell pluripotency and has been
shown as a useful immunohistochemical marker for germ cell tumors. However, information …

SALL4, a member of the SALL family, is an embryonic stem cell regulator involved in self-
renewal and pluripotency. Recently, SALL4 overexpression was found in malignant cancers …

There is a growing body of evidence supporting that cancer cells share many similarities
with embryonic stem cells (ESCs). For example, aggressive cancers and ESCs share a …

Gastric cancer (GC) is regarded as the fifth most common cancer and the third cause of
cancer-related deaths worldwide. Mechanism of GC pathogenesis is still unclear and relies …

Melanoma cells rely on developmental programs during tumor initiation and progression.
Here we show that the embryonic stem cell (ESC) factor Sall4 is re-expressed in the Tyr …

SALL4 is a transcription factor that plays essential roles in maintaining self-renewal and
pluripotency of embryonic stem cells (ESCs). In fully differentiated cells, SALL4 expression is …

Simple Summary Transcription factors play essential roles in regulating gene expression,
impacting the cell phenotype and function, and in the response of cells to environmental …

Gastric and colorectal cancers have a high incidence and mortality worldwide. The presence
of cancer stem cells (CSCs) within the tumor mass has been indicated as the main reason …