The study of eukaryotic tRNA processing has given rise to an explosion of new information
and insights in the last several years. We now have unprecedented knowledge of each step …

The principles of mRNA decoding are conserved among all extant life forms. We present an
integrative view of all the interaction networks between mRNA, tRNA and rRNA: the intrinsic …

Following synthesis, tRNAs are peppered by numerous chemical modifications which may
differentially affect a tRNA's structure and function. Although modifications affecting the …

N 6-methylation of adenosine (forming m6A) is the most abundant post-transcriptional
modification within the coding region of mRNA, but its role during translation remains …

Nucleic acid modifications in DNA and RNA ubiquitously exist among all the three kingdoms
of life. This trait significantly broadens the genome diversity and works as an important …

ABSTRACT A simple post-transcriptional modification of tRNA, deamination of adenosine to
inosine at the first, or wobble, position of the anticodon, inspired Francis Crick's Wobble …

Pseudouridine (Ψ) is the most abundant of> 150 nucleoside modifications in RNA. Although
Ψ was discovered as the first modified nucleoside more than half a century ago, neither the …

RNAs are central to all gene expression through the control of protein synthesis. Four major
nucleosides, adenosine, guanosine, cytidine and uridine, compose RNAs and provide …

RNA dynamics play a fundamental role in many cellular functions. However, there is no
general framework to describe these complex processes, which typically consist of many …

Posttranscriptional modifications at the wobble position of transfer RNAs play a substantial
role in deciphering the degenerate genetic code on the ribosome. The number and variety of …