Envelope biogenesis and homeostasis in gram-negative bacteria are exceptionally intricate
processes that require a multitude of periplasmic chaperones to ensure cellular survival …

The folding of proteins into their native structure is crucial for the functioning of all biological
processes. Molecular chaperones are guardians of the proteome that assist in protein …

Many RNA-binding proteins (RBPs), particularly those associated with RNA granules,
promote pathological protein aggregation in neurodegenerative diseases. Here, we …

The survival and virulence of Gram-negative bacteria require proper biogenesis and
maintenance of the outer membrane (OM), which is densely packed with β-barrel OM …

Periplasmic chaperones 17-kilodalton protein (Skp) and survival factor A (SurA) are
essential players in outer membrane protein (OMP) biogenesis. They prevent unfolded …

Proper folding is essential for the biological functions of all proteins. The folding process is
intrinsically error-prone, and the misfolding of a polypeptide chain can cause the formation …

Molecular chaperones are central to cellular protein homeostasis. Dynamic disorder is a key
feature of the complexes of molecular chaperones and their client proteins, and it facilitates …

In the Gram-negative bacteria, many important virulence factors reach their destination via
two-step export systems, and they must traverse the periplasmic space before reaching the …

Peroxiredoxins (PRDXs) are abundant peroxidases present in all kingdoms of life. Recently,
they have been shown to also carry out additional roles as molecular chaperones. To …

The biogenesis of integral β-barrel outer membrane proteins (OMPs) in gram-negative
bacteria requires transport by molecular chaperones across the aqueous periplasmic space …